内容説明
Written and edited by world-renowned authorities, this three-volume work is, to quote a reviewer, "the definitive textbook about seizures and epilepsy". This Second Edition is thoroughly updated and gives you a complete print and multimedia package: the three-volume set plus access to an integrated content Website.
More than 300 chapters cover the spectrum of biology, physiology, and clinical information, from molecular biology to public health concerns in developing countries. Included are detailed discussions of seizure types and epilepsy syndromes; relationships between physiology and clinical events; psychiatric and medical comorbidity; conditions that could be mistaken for epilepsy; and an increasing range of pharmacologic, surgical, and alternative therapies, including vagus nerve stimulation and deep brain stimulation. This edition describes many new antiepileptic drugs, major advances in surgical treatment, and state-of-the-art neuroimaging, EEG, and other technologies for diagnosis and seizure prediction.
A companion Website offers instant access to the complete, fully searchable text, plus an image bank of additional figures, video footage, and annual updates to selected chapters.
目次
VOLUME I
Introduction: What Is Epilepsy?
SECTION 1 EPIDEMIOLOGY, PATHOLOGY, AND GENETICS OF EPILEPSY
Overview: Epidemiology, Pathology, and Genetics
Epilepsy: Historical Perspectives Neuropathology
EPIDEMIOLOGY
Incidence and Prevalence
The Natural History and Prognosis of Epilepsy
NEUROPATHOLOGY
General Neuropathology of Epilepsy
Hippocampal Sclerosis
GENETICS
Genetic Epidemiology
EEG Traits
SECTION II THE NEUROBIOLOGY OF EPILEPSY
Overview: The Neurobiology of Epilepsy
MECHANISMS OF NORMAL NEURONAL EXCITABILITY
Control of Neuronal Excitability
Excitatory Synaptic Transmission
Neocortical Anatomy and Physiology
Thalamocortical Anatomy and Physiology
MECHANISMS OF EPILEPTOGENESIS AND EPILEPTOGENICITY
Genetic Models of Epilepsy
Seizure Mechanisms and Vulnerability in the Developing Brain
SECTION III PHENOMENOLOGY
Overview: Phenomenology
EPILEPTIC SEIZURES
Simple Motor Seizures
Limbic Seizures
Epileptic Spasms
STATUS EPILEPTICUS
Generalized Convulsive Status Epilepticus
Absence Status Epilepticus
Myoclonic Status Epilepticus
EPILEPTIC DISORDERS
Classification of the Epilepsies
SECTION IV DIAGNOSTIC EVALUATION
Overview: Diagnostic Evaluation
ROUTINE INVESTIGATIONS
History and Physical Examination
EEG
Physiologic Basis of the Electroencephalogram and Local Field Potentials
Ictal Electroencephalogram
Polygraphic Recordings
NEUROIMAGING
Positron Emission Tomography
Magnetic Resonance Spectroscopy
Computational Anatomy
NEW DIRECTIONS
Seizure Prediction
Microdialysis
Transcranial Magnetic Stimulation
Cellular Imaging of Epilepsy
NEUROPSYCHOLOGICAL EVALUATION
LONG-TERM MONITORING
VOLUME II
SECTION V GENERAL TREATMENT CONSIDERATIONS
Overview: General Approaches to Treatment
GENERAL CONSIDERATIONS
PRINCIPLES OF DRUG TREATMENT
STRATEGIES FOR PHARMACOTHERAPY
SPECIAL THERAPEUTIC CONSIDERATIONS
ALTERNATIVE APPROACHES
SECTION VI ANTIEPILEPTIC DRUGS
ANTIEPILEPTIC DRUG DEVELOPMENT
ANTIEPILEPTIC DRUGS
SECTION VII SURGICAL THERAPY
CANDIDATE SELECTION
INVASIVE MONITORING TECHNIQUES
FUNCTIONAL MAPPING TECHNIQUES
THERAPEUTIC SURGICAL PROCEDURES
POSTOPERATIVE FOLLOW-UP
SECTION VIII CLINICAL BIOLOGY OF EPILEPSY>/B>
BIORHYTHMS AND THE AUTONOMIC NERVOUS SYSTEM
COMORBIDITY
NEUROENDOCRINOLOGY
VOLUME III
SECTION IX PSYCHIATRIC AND SOCIAL ISSUES
PSYCHIATRIC ISSUES
SOCIAL ISSUES
SECTION X EPILEPSY SYNDROMES
NEONATAL SYNDROMES
SYNDROMES OF INFANCY AND EARLY CHILDHOOD
SYNDROMES OF LATER CHILDHOOD AND ADOLESCENCE
NON AGE-RELATED AND SPECIAL SYNDROMES
DISEASES ASSOCIATED WITH EPILEPSY
SECTION XI DISORDERS THAT CAN BE CONFUSED WITH EPILEPSY
SYSTEMIC DISTURBANCES
NEUROLOGICAL DISTURBANCES
PSYCHIATRIC DISTURBANCES
SECTION XII DELIVERY OF HEALTH CARE AND SOCIOECONOMIC ISSUES
ORGANIZATION OF HEALTH CARE IN DIFFERENT COUNTRIES
SPECIALIZED CENTERS FOR EPILEPSY
COST AND ALLOCATION OF RESOURCES
Subject Index
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