CiNii 図書 - Chemokine research trends

Chemokines are the cytokines that may activate or chemoattract leukocytes. Each chemokine contains 65-120 amino acids, with molecular weight of 8-10 kD. Their receptors belong to G-protein-coupled receptors. Inflammatory chemokines are released from a wide variety of cells in response to bacterial infection, viruses and agents that cause physical damage such as silica or the urate crystals that occur in gout. They function mainly as chemoattractants for leukocytes, recruiting monocytes, neutrophils and other effector cells from the blood to sites of infection or damage. They can be released by many different cell types and serve to guide cells involved in innate immunity and also the lymphocytes of the adaptive immune system. The cells that are attracted by chemokines follow a signal of increasing chemokine concentration to the site of infection or tissue injury. Some chemokines also have roles in the development of lymphocytes, migration and angiogenesis (the growth of new blood vessels).Since the entry of HIV into host cells requires chemokine receptors, their antagonists are being developed to treat AIDS.

Chemokines and Mycobacterial Infection: Critical Roles of The TLRs, and their Signalling Pathways
Herpes Simplex Virus Type 1 Suppresses Type I Interferon-Induced Chemokine Production in Trigeminal Ganglion Cell Cultures
The Role of Chemokines in the Pathogenesis of HIV-1 during HIV-1/Tb dual infection
Role of Chemokines in Rheumatic Disorders
Smoking and acahemokine Levels
Targeting MIP-1 and its Receptor CCR5 in Rodent Models of Rheumatoid Arthritis
The Role of Chemokine MCP-1 and its Receptor CCR2 in Neuropathic Pain
CCL2 and CCL3 Chemokines and Rankl stimulate Chemotaxis of Human Monocytes through distinct Intracellular Kinase Pathways
The Importance of the CCL27-CCR10 Chemokine Ligand-Receptor Interaction in Melanoma: An Immunohistochemical Study
Cross Talk between Chemokine Receptor CXCR4 and Oncoproteins in Tumour Progression and Roles of Platelet-derived Chemokines in Various Clinical Settings
The Role of the CXCL16-CXCR6 Pathway in Cell Recruitment, Activation and Effector Functions
Novel Aspects of Amniotic Fluid Examination for Chorioamnionitis
Anti-inflammatory Effects of Nifedipine, a Dihydropyridine-based Calcium Blocker, on Endothelial Cells
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Chemokine research trends

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