Aging of the genome : the dual role of DNA in life and death

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書誌事項

Aging of the genome : the dual role of DNA in life and death

Jan Vijg

Oxford University Press, 2007

  • : hbk. : alk. paper
  • pbk

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注記

Includes bibliographical references (p. [309]-351) and index

内容説明・目次

内容説明

Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.

目次

  • Preface
  • 1. Introduction
  • 2. The Logic of Aging
  • 3. Genome Structure and Function
  • 4. Genome Maintenance
  • 5. Genome Instability and Accelerated Aging
  • 6. The Aging Genome
  • 7. From Genome to Phenome
  • 8. A Genomic Limit to Life?
  • References and Glossary
  • Literature References

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