Cancer drug resistance

Author(s)

• Teicher, Beverly A.

Bibliographic Information

Cancer drug resistance

edited by Beverly A. Teicher

（Cancer drug discovery and development）

Humana Press, c2006

Note

Includes bibliographical references and index

Description and Table of Contents

Description

Leading experts summarize and synthesize the latest discoveries concerning the changes that occur in tumor cells as they develop resistance to anticancer drugs, and suggest new approaches to preventing and overcoming it. The authors review physiological resistance based upon tumor architecture, cellular resistance based on drug transport, epigenetic changes that neutralize or bypass drug cytotoxicity, and genetic changes that alter drug target molecules by decreasing or eliminating drug binding and efficacy. Highlights include new insights into resistance to antiangiogenic therapies, oncogenes and tumor suppressor genes in therapeutic resistance, cancer stem cells, and the development of more effective therapies. There are also new findings on tumor immune escape mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

Table of Contents

Part I. Physiological Resistance The Cycle Between Angiogenesis, Perfusion, and Hypoxia in Tumors Mark W. Dewhirst, Yiting Cao, Benjamin Moeller, and Chuan-Yuan Li Influence of Tumor pH on Therapeutic Response Chang W. Song, Robert Griffin, and Heon Joo Park Tumor Oxygenation and Treatment Response Sarah Jane Lunt and Richard P. Hill Oncogenes and Tumor Suppressor Genes in Therapeutic Resistance: The Role of Evolving Interrelationships Between Cancer Cells and Host Tissues Janusz W. Rak, Brenda Coomber, and Joanne L. Yu PET Imaging of Response and Resistance to Cancer Therapy David A. Mankoff and Kenneth A. Krohn Part II: Biological Resistance Cancer Stem Cells: Implications for Development of More Effective Therapies Ilia Mantle, Gabriela Dontu, Suling Liu, and Max S. Wicha Therapeutic Resistance in Leukemia William R. Waud Tumor Site Implantation and Animal Model Selection in Oncology Anibal A. Arjona and Enrique Alvarez In Vivo Resistance Beverly A. Teicher Characteristics of the Metastatic Phenotype: The Melanoma Experience Vladislava O. Melnikova and Menashe Bar-Eli The Microenvironment and Drug Resistance Patrice J. Morin Part III. Biochemical Resistance Glutathione and Glutathione S-Transferases in Drug Resistance Victoria J. Findlay, Danyelle M. Townsend, and Kenneth D. Tew Metallothioneins in Drug Resistance Faiyaz Notta and D. James Koropatnick Molecular Determinants of Intrinsic Multidrug Resistance in Cancer Cells and Tumors Elena Monti New and Revised Concepts in Multidrug Resistance: Sestamibi, SNPs, Substrates, and Stem Cells Susan E. Bates, John Deeken, Chaohong Fan, and Robert W. Robey Cisplatin Resistance: Molecular Basis of a Multifaceted Impediment Zahid H. Siddik Regulation of the Cellular Pharmacology and Cytotoxicity of Cisplatin by Copper Transporters Roohangiz Safaei and Stephen B. Howell Resistance to Taxanes Lee M. Greenberger and Deepak Sampath CpG Island Methylation and Drug Resistance Jens M. Teodoridis and Robert Brown De Novo and Acquired Resistance to Antitumor Alkylating Agents Lori A. Hazlehurst and William S. Dalton Resistance to Antiangiogenic Agents George W. Sledge, Jr., Kathy D. Miller, Bryan Schneider, and Christopher J. Sweeney Part IV. The Role of Hormones, Growth Factors, and Oncogenes Resistance to Antiestrogens Clodia Osipo and Ruth M. O'Regan Mechanisms of Glucocorticoid Actions and Resistance in Multiple Myeloma Varsha Gandhi and Beatriz Sanchez-Vega Herceptin Resistance Ingrid A. Mayer and Carlos L. Arteaga Role of TGF-b in Tumor Progression and Metastasis Jan Pinkas and Beverly A. Teicher p53-Based Immunotherapy of Cancer Albert B. DeLeo Response and Resistance to Ionizing Radiation Paul Dent, Adly Yacoub, Michael P. Hagan, and Steven Grant Amplification in DNA Copy Numbers as a Mechanism of Acquired Drug Resistance M. Jim Yen, Ie-Ming Shih, Victor E. Velculescu, and Tian-Li Wang Part V. Clinical Aspects of Resistance Cancer Chemotherapy: Clinical Evidence for Drug Resistance Mika A. Sovak and David R. Spriggs Molecular Profiling in Breast Cancer: Genomic Approaches Toward Tailored Cancer Therapies Kristin Kee and Jeffrey E. Green Tumor Immune Escape Mechanisms Yi Ting Koh, M. Luz Garcia-Hernandez, and W. Martin Kast Index

by "Nielsen BookData"

Details

• NCID: BA8455177X
• ISBN:
  • 1588295303
• LCCN: 2005052500
• Country Code: us
• Title Language Code: eng
• Text Language Code: eng
• Place of Publication: Totowa, N.J.
• Pages/Volumes: xvi, 617 p.
• Size: 26 cm
• Classification:
  • LCC : RC271.C5
  • NLM : 2006 G-128
  • NLM : QZ 267
  • DC22 : 616.99/4061
• Subject Headings:
  • LCSH : Drug resistance in cancer cells
  • MESH : Drug Resistance, Neoplasm
  • MESH : Antineoplastic Agents -- therapeutic use
• Parent Bibliography ID:
  • BA36585533