Alternative splicing in the postgenomic era
著者
書誌事項
Alternative splicing in the postgenomic era
（Advances in experimental medicine and biology, v. 623）
Springer Science+Business Media , Landes Bioscience, c2007
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Yet again Springer has reached the market before everyone. This is the first book that is solely dedicated to the topic of alternative splicing. The book contains chapters by experts in the field that cover nearly all aspects of this hugely important subject. The purpose of the text is to provide a single, authoritative source of information on alternative splicing that is accessible to researchers in diverse fields. It is suitable for beginners and experts alike.
目次
CONTENTS FOREWORD......................................................................................................... v PREFACE.............................................................................................................. ix ABOUT THE EDITOR S.................................................................................... xiii PARTICI PANTS.................................................................................................. xv 1. Nuclear Organization and Splicing Control..................... 1 Maria Carmo-Fonseca and Celia Carvalho Abstract................................................................................................................................. 1 Splicing and the Nucleus...................................................................................................... 1 Compartmentalization of Splicing and Splicing Factors.................................................. 3 Compartmentalization of Splicing Factors and Splicing Regulation............................... 8 Perspectives.......................................................................................................................... 9 2. Spliceosome Assembly and Composition............................... 14 Arianne J. Matlin and Melissa J. Moore Abstract............................................................................................................................... 14 Introduction........................................................................................................................ 14 Composition and Structure................................................................................................ 14 In Vitro Spliceosome Assembly.......................................................................................... 15 Product Release and snRNPRecycling............................................................................. 24 Interactions at the Ends of Transcripts That Promote Spliceosome Assembly................................................................................................ 24 The Holospliceosome Hypothesis...................................................................................... 24 Insights from In Vivo Analysis of Spliceosome Assembly............................................... 25 Commitment to Particular Splice Sites............................................................................. 26 Proofreading....................................................................................................................... 26 Final Comments.................................................................................................................. 28 3. Relating Alternative Splicing to Proteome Complexity and Genome Evolution.................................. 36 Yi Xing and Christopher Lee Abstract............................................................................................................................... 36 Alternative Splicing and Proteomic Complexity.............................................................. 36 Alternative Splicing of Protein Domains and Functional Sites...................................... 37 Alternative Splicing and Protein Structure...................................................................... 39 Alternative Splicing and Genome Evolution.................................................................... 40 Alternative Splicing and Amino Acid Mutation Selection Pressure............................... 43 Alternative Splicing and RNA Selection Pressure........................................................... 43 Connecting RNA Selection Pressure to Real Splicing
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