Sunlight, vitamin D and skin cancer
著者
書誌事項
Sunlight, vitamin D and skin cancer
（Advances in experimental medicine and biology, v. 624）
Springer Science+Business Media , Landes Bioscience, c2008
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
The goal of this volume is to offer a highly readable and comprehensive overview on our present knowledge of the positive and negative effects of UV-exposure. The book focuses on vitamin D and skin cancer. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in endocrinology, epidemiology, histology, photobiology, immunology, cytogenetics and molecular pathology to new concepts for prophylaxis and treatment.
目次
CONTENTS 1. Sunlight, UV-Radiation, Vitamin D and Skin Cancer: How Much Sunlight Do We Need?....................................................... 1 Michael F. Holick Abstract................................................................................................................................. 1 Prehistorical and Historic Perspectives.............................................................................. 1 Photoproduction of Vitamin D3............................................................................................ 2 Factors Controlling Cutaneous Vitamin D Synthesis........................................................ 2 Sources and Metabolism of Vitamin D................................................................................ 4 Role of Vitamin D in the Prevention of Chronic Diseases................................................. 5 Vitamin D Deficiency Pandemic.......................................................................................... 7 Sunlight, Vitamin D and the Skin Cancer Conundrum.................................................... 7 Conclusion.......................................................................................................................... 10 2. Solar Ultrav iolet Irradiance and Cancer Incidence and Mortality...................................................................... 16 William B. Grant Introduction........................................................................................................................ 16 Cancer................................................................................................................................. 16 Other Diseases for Which Solar UVB and Vitamin D Are Beneficial/Protective.......... 25 Summary and Conclusion.................................................................................................. 25 3. Vitamin D Status and Cancer Incidence and Mortality............................................................................................. 31 Edward Giovannucci Introduction........................................................................................................................ 31 Ecologic Studies of Sun Exposure..................................................................................... 32 Case-Control and Cohort Studies of Sun Exposure........................................................ 32 Prospective Studies of Circulating 25(OH)vitamin D and Cancer Risk........................ 33 Studies of Vitamin D Intake............................................................................................... 35 Randomized Trial of Vitamin D Intake and Colorectal Cancer..................................... 36 Solar Radiation, Vitamin D and Survival Rate of Colon Cancer................................... 36 Vitamin D and Cancer Rates in United States Black Men.............................................. 37 Synthesis of Evidence Regarding Sun Exposure, Vitamin D and Cancer Incidence and Mortality........................................................................ 38 Implications for Future Research...................................................................................... 39 4. Sun Exposure and Cancer Surviva l in Norway: Changes in the Risk of Death with Season of Diagnosis and Latitude.................................................................... 43 Alina Carmen Porojnicu, Arne Dahlback and Johan Moan Abstract............................................................................................................................... 43 Introduction.............................................
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