DNA methylation research trends
著者
書誌事項
DNA methylation research trends
Nova Biomedical Books, c2007
大学図書館所蔵 全1件
注記
Includes bibliographical references and index
収録内容
- Investigation of the CpG effect in mammalian genomes / Zhongming Zhao and Cizhong Jiang
- CpG islands in plants / Ikuo Ashikawa
- Epigenetic roles of CpG methylation at non-CpG-islands revealed by morphology-oriented epigenetic research / Sohei Kitazawa ... [et al.]
- DNA methyltransferase inhibitors as therapeutic agents in hematological malignancies / Takashi Kumagai and H. Phillip Koeffler
- Analysis of DNA methylation patterns for the early diagnosis, classification and therapy of human cancers / Jörg Tost
- DNA methylation changes in pathogenesis and therapy of hematopoietic malignancies / Edgar Jost, Rainhardt Osieka, and Oliver Galm
- DNA methylation and tumor suppression / Iftikhar Qayum and Muhammad Ashraf
- Methylation and loss of heterozygosity in cancer are linked by siRNA? / Coral Wynter, Marcelo Alfonzo, and Itala Lippo de Becemberg
- Methylation in cancer research / Juan Carlos Roa and Patricia García
内容説明・目次
内容説明
DNA methylation is a type of chemical modification of DNA that can be inherited without changing the DNA sequence. As such, it is part of the epigenetic code and is the most characterised epigenetic mechanism. DNA methylation involves the addition of a methyl group to DNA -- for example, to the number 5 carbon of the cytosine pyrimidine ring. DNA methylation is probably universal in eukaryotes. In humans, approximately 1% of DNA bases undergo DNA methylation. In adult somatic tissues, DNA methylation typically occurs in a CpG dinucleotide context; non-CpG methylation is prevalent in embryonic stem cells.In plants, cytosines are methylated both symmetrically (CpG or CpNpG) and asymmetrically (CpNpNp), where N can be any nucleotide. The methylation status of specific cytosines can be determined using methods based on bisulfite sequencing. This book presents new and important research from around the world in this field.
目次
- Preface
- Research and Review Studies
- Investigation of the CpG Effect in Mammalian Genomes
- CpG Islands in Plants
- Epigenetic Roles of CpG Methylation at Non-CpG-Islands revealed by Morphology-Oriented Epigenetic Research
- DNA Methyltransferase Inhibitors as Therapeutic Agents in Hematological Malignancies
- Analysis of DNA Methylation Patterns for the Early Diagnosis, Classification and Therapy of Human Cancers
- DNA Methylation Changes in Pathogenesis and Therapy of Hematopoietic Malignancies
- DNA Methylation and Tumour Suppression
- Methylation and Loss of Heterozygosity in Cancer are linked by siRNA?
- Methylation in Cancer Research
- Index.
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