Folate and human development
著者
書誌事項
Folate and human development
Humana Press, c2002
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
An authoritative panel of basic and clinical researchers critically reviews the latest findings on the role of folate in human development, health, and disease. Specific areas addressed include folate metabolism in zinc or copper deficiencies, choline and folate in development, animal models of folate-related birth defects, developmental toxicants potentially acting via folate perturbation, and folate's role in vascular disease in women. There are also cutting-edge discussions of genes and neural tube development, folate receptor polymorphism and the risk for neural defects, abnormal DNA synthesis and methylation with folate/methyl insufficiency, and folic acid and homocysteine as risk factors for neural tube defects.
目次
Animal Models of Folate-Related Neural Tube Defects
Nicholas D. E. Greene and Andrew J. Copp
Genetic Variation in Folate Metabolism: Impact on Development
Rima Rozen
Folate Deficiency and the Molecular Determinants of Chromosome Instability: Possible Link to Meiotic Nondisjunction and Down Syndrome
S. Jill James and Charlotte A. Hobbs
Folic Acid, Vitamin B12, and Genomic Stability of Human Cells
Michael Fenech
Molecular Genetics of Folate Metabolism
Manuela Foedinger, Sonja Skoupy, and Gere Sunder-Plassmann
Folate Receptor-a: An Update
Barton A. Kamen
Folate, Homocysteine, and Neural Tube Defects
Tom K. A. B. Eskes
Folic Acid and Homocysteine as Risk Factors for Neural Tube Defects
Robert C. Barber, Janee van Waes, Edward J. Lammer, Gary M. Shaw, Thomas H. Rosenquist, and Richard H. Finnell
Developmental Toxicants Potentially Acting via Folate Perturbation
Deborah K. Hansen
Brain Development and Choline, the Other Methyl Donor
Steven H. Zeisel
Nutrient Interactions Between Folate and Zinc or Copper: Their Possible Implications to Pregnancy Outcome
Tsunenobu Tamura
Regulation of Folate Metabolism by Iron
A. Katherine Herbig and Patrick J. Stover
A Differential Role for Folate in Developmental Disorders, Vascular Disease, and Other Clinical Conditions: The Importance of Folate Status and Genotype
Mark Lucock and Zoe Yates
Vascular Disease in Women: Folate and Homocysteine
Tom K. A. B. Eskes
Folate, Homocysteine, and Cardiovascular Disease
Jayne V. Woodside and Ian S. Young
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