Pediatric traumatic brain injury : from molecular mechanisms to clinical research

著者

    • Robertson, Courtney L.
    • Mckenna, Mary C.

書誌事項

Pediatric traumatic brain injury : from molecular mechanisms to clinical research

guest editors, Courtney L. Robertson, Mary C. McKenna

（Developmental neuroscience, v. 28, no. 4-5, 2006）

Karger, c2006

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

Trauma is the leading cause of death in children, and traumatic brain injury is the main determinant of morbidity and mortality. Despite these statistics, there are relatively few studies and a critical need for effective, pediatric specific neuroprotective interventions. Authored by internationally recognized basic scientists and clinician investigators, this special issue discusses the clinically important, rapidly evolving field of pediatric traumatic brain injury. It encompasses a wide range from clinical studies to research on the biochemical, cellular and molecular mechanisms of acute brain injury and secondary damage following traumatic brain injury. It is well documented that the developing brain is very different from the adult brain, and effective treatments must protect from acute and secondary damage and allow for appropriate brain growth and development during the recovery phase. This volume incorporates a wealth of knowledge and points to new areas for future research. It will serve as a valuable and comprehensive reference work for neurobiologists, pediatric intensivists, neurologists, neurosurgeons, neonatologists, neuroradiologists and investigators in the field of neuroprotection.

目次

  • Preface: Robertson, C.L.
  • McKenna, M.C.
  • Overview
  • Pediatric Traumatic Brain Injury: Quo Vadis?: Kochanek, P.M.
  • Clinical Research
  • Epidemiology and Outcomes of Pediatric Traumatic Brain Injury: Keenan, H.T.
  • Bratton, S.L.
  • Pediatric Traumatic Brain Injury: Past, Present and Future: Jankowitz, B.T.
  • Adelson, P.D.
  • Clinical Trials in Pediatric Traumatic Brain Injury: Unique Challenges and Potential Responses: Natale, J.E.
  • Joseph, J.G.
  • Pretzlaff, R.K.
  • Silber, T.J.
  • Guerguerian, A.-M.
  • Hypothermia Pediatric Head Injury Trial: The Value of a Pretrial Clinical Evaluation Phase: Hutchison, J.
  • Ward, R.
  • Lacroix, J.
  • Hebert, P.
  • Skippen, P.
  • Barnes, M.
  • Meyer, P.
  • Morris, K.
  • Kirpalani, H.
  • Singh, R.
  • Dirks, P.
  • Bohn, D.
  • Moher, D. for the HyP-HIT Investigators and the Canadian Critical Care Trials Group
  • Changes in White Matter Late after Severe Traumatic Brain Injury in Childhood: Tasker, R.C.
  • Use of Advanced Neuroimaging Techniques in the Evaluation of Pediatric Traumatic Brain Injury: Ashwal, S.
  • Holshouser, B.A.
  • Tong, K.A.
  • Serum Biomarkers after Traumatic and Hypoxemic Brain Injuries: Insight into the Biochemical Response of the Pediatric Brain to Inflicted Brain Injury: Pardes Berger, R.
  • Adelson, P.D.
  • Richichi, R.
  • Kochanek, P.M.
  • Mitochondrial Heat Shock Protein 60 Is Increased in Cerebrospinal Fluid following Pediatric Traumatic Brain Injury: Lai, Y.
  • Stange, C.
  • Wisniewski, S.R.
  • Adelson, P.D.
  • Janesko-Feldman, K.L.
  • Brown, D.S.
  • Kochanek, P.M.
  • Clark, R.S.B.
  • Heme Oxygenase 1 in Cerebrospinal Fluid from Infants and Children after Severe Traumatic Brain Injury: Cousar, J.L.
  • Lai, Y.
  • Marco, C.D.
  • Bayir, H.
  • Adelson, P.D.
  • Janesko-Feldman, K.L.
  • Kochanek, P.M.
  • Clark, R.S.B.
  • Impaired Cerebral Autoregulation and 6-Month Outcome in Children with Severe Traumatic Brain Injury: Preliminary Findings: Vavilala, M.S.
  • Muangman, S.
  • Tontisirin, N.
  • Fisk, D.
  • Roscigno, C.
  • Mitchell, P.
  • Kirkness, C.
  • Zimmerman, J.J.
  • Chesnut, R.
  • Lam, A.M.
  • Pediatric Posttraumatic Seizures: Epidemiology, Putative Mechanisms of Epileptogenesis and Promising Investigational Progress: Statler, K.D.
  • Basic Science Research
  • Is Being Plastic Fantastic? Mechanisms of Altered Plasticity after Developmental Traumatic Brain Injury: Giza, C.C.
  • Prins, M.L.
  • Large Animal Models of Traumatic Injury to the Immature Brain: Duhaime, A.-C.
  • Predicting Unconsciousness from a Pediatric Brain Injury Threshold: Zhu, Q.
  • Prange, M.
  • Margulies, S.
  • Traumatic Injury to the Immature Brain Results in Progressive Neuronal Loss, Hyperactivity and Delayed Cognitive Impairments: Pullela, R.
  • Raber, J.
  • Pfankuch, T.
  • Ferriero, D.M.
  • Claus, C.P.
  • Koh, S.-E.
  • Yamauchi, T.
  • Rola, R.
  • Fike, J.R.
  • Noble-Haeusslein, L.J.
  • Gel-Based Hippocampal Proteomic Analysis 2 Weeks following Traumatic Brain Injury to Immature Rats Using Controlled Cortical Impact: Kochanek, A.R.
  • Kline, A.E.
  • Gao, W.-M.
  • Chadha, M.
  • Lai, Y.
  • Clark, R.S.B.
  • Dixon, C.E.
  • Jenkins, L.W.
  • Oxidative Stress in Immature Brain after Traumatic Brain Injury: Bayir, H.
  • Kochanek, P.M.
  • Kagan, V.E.
  • The Potential Role of Mitochondria in Pediatric Traumatic Brain Injury: Robertson, C.L.
  • Soane, L.
  • Siegel, Z.T.
  • Fiskum, G.
  • Induction of Monocarboxylate Transporter 2 Expression and Ketone Transport following Traumatic Brain Injury in Juvenile and Adult Rats: Prins, M.L.
  • Giza, C.C.
  • Alpha-II-Spectrin after Controlled Cortical Impact in the Immature Rat Brain: Aikman, J.
  • O'Steen, B.
  • Silver, X.
  • Torres, R., Boslaugh, S.
  • Blackband, S.
  • Padgett, K.
  • Wang, K.K.W.
  • Hayes, R.
  • Pineda, J.
  • Regionally Distinct Patterns of Calpain Activation and Traumatic Axonal Injury following Contusive Brain Injury in Immature Rats: Huh, J.W.
  • Franklin, M.A.
  • Widing, A.G.
  • Raghupathi, R..

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