Mechanisms of insulin action
著者
書誌事項
Mechanisms of insulin action
（Medical intelligence unit）
Landes Bioscience , Springer Science + Business Media, c2007
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.
目次
Insulin and IGF-I Receptor Structure and Binding Mechanism.- Subcellular Compartmentalization of Insulin Signaling Processes and GLUT4 Trafficking Events.- Regulation of Insulin Action and Insulin Secretion by SNARE-Mediated Vesicle Exocytosis.- Control of Protein Synthesis by Insulin.- Hepatic Regulation of Fuel Metabolism.- Insulin Action Gene Regulation.- Insulin Action in the Islet ?-Cell.- Central Regulation of Insulin Sensitivity.- Transgenic Models of Impaired Insulin Signaling.- Insulin Resistance.
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