Mechanisms of insulin action

著者

    • Saltiel, Alan R.
    • Pessin, Jeffrey E.

書誌事項

Mechanisms of insulin action

Alan R. Saltiel, Jeffrey E. Pessin

(Medical intelligence unit)

Landes Bioscience , Springer Science + Business Media, c2007

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.

目次

Insulin and IGF-I Receptor Structure and Binding Mechanism.- Subcellular Compartmentalization of Insulin Signaling Processes and GLUT4 Trafficking Events.- Regulation of Insulin Action and Insulin Secretion by SNARE-Mediated Vesicle Exocytosis.- Control of Protein Synthesis by Insulin.- Hepatic Regulation of Fuel Metabolism.- Insulin Action Gene Regulation.- Insulin Action in the Islet ?-Cell.- Central Regulation of Insulin Sensitivity.- Transgenic Models of Impaired Insulin Signaling.- Insulin Resistance.

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