Progestins and antiprogestins in clinical practice
著者
書誌事項
Progestins and antiprogestins in clinical practice
Marcel Dekker, c2000
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This comprehensive ready-reference guide thoroughly examines the physiological aspects of progestins and their role at the receptor level, focusing on reproductive activity, menopausal treatment, and related areas. The book presents vital research findings on the clinical use of progesterone and related derivatives, plus key applications of antiprogestins.
Illuminates progesterone's remarkable power in hormonal contraception and regulation of the hypothalamo-pituitary complex!
Written by more than 25 leading international experts on women's health, Progestins and Antiprogestins in Clinical Practice
explains the effects of long-term controlled progestin studies on breast tissue
discusses the nuclear localization of steroid hormone receptors
covers the relationship of CDK activity and cell proliferation
analyzes production of progesterone metabolites and precursors synthesized locally within the brain and in the endocrine glands
describes cardiovascular effects associated with combined oral contraceptives (COCs), highlighting carbohydrate and lipid metabolism and hematological factors
investigates the epidemiology of estrogen-induced endometrial hyperplasia and/or cancer
demonstrates cases in which minor structural modifications in some steroid molecules can affect biological function
explores several properties of progesterone and its natural derivatives
illustrates instances of cloning of the intracellular progesterone receptor (PR) in several species
assesses direct progesterone action in target tissues and indirect effects of progesterone regulation
surveys properties of widely used contraceptive steroids, such as norethindrone (NET) plus estradiol (E2), levonorgestrel (LNG) plus estradiol (E2), nestorone plus ethinyl estradiol (EE2), and NET acetate plus EE2
reviews the efficacy and safety of newer contraceptive strategies such as Norplant implants and vaginal rings
covers applications of RU486 (mifepristone)
and more!
目次
Physiological Aspects
Structure of the Progesterone Receptor and Mode of Action of Progesterone,
Anne Guiochon-Mantel
Effects of Progesterone and Related Steroids in the Brain,
Martine El-Etr, Michael Schumacher, and Etienne-Emile Baulieu
Effects of Progestin on the Breast: Regulation of Cell Cycle Progression by Progestins,
Elizabeth A. Musgrove and Robert L. Sutherland
Vaginal Progesterone: Direct Access to the Uterus, Physiological Hormone Replacement in Infertility and Gynecology,
Dominique de Ziegler, Carlo Bulletti, and Ettore Cicinelli
Pharmacology of Synthetic Progestins
Pharmacology of Progestins: 17 -Hydroxyprogesterone Derivatives and Progestins of the First and Second Generation,
Milan Rastislav Henzl and John A. Edwards
Clinical Pharmacology of Third-Generation Gestogens,
Kenneth Fotherby
Pharmacology of New Progestogens: The 19-Norprogesterone Derivatives,
Regine Sitruk-Ware and Kalyan Sundaram
Hybrid Progestins: The Example of Dienogest,
Michael Oettel and Cornelia Holz
Clinical Applications
Contraception
Progestogens in Contraception: Third-Generation Pills,
Ulysse J. Gaspard
Levonorgestrel-Releasing Contraceptive Implants,
C. Wayne Bardin
Progestin-Releasing Intrauterine Devices,
Tapani Luukkainen
Contraceptive Vaginal Rings,
Donna Shoupe and Daniel R. Mishell, Jr.
Progestins for Emergency Contraception,
Andre Ulmann
Menopause
Progestins in Hormonal Replacement Therapy and Prevention of Endometrial Disease,
Regine Sitruk-Ware
Progestins in Postmenopausal Women: Epidemiological Data on Relationships with Endometrial and Breast Cancer Risk,
Timothy J. Key
Progestins in Hormonal Replacement Therapy and Cardiovascular Risk,
Regine Sitruk-Ware
Breast Diseases
Control of Estrogen's Effects by Progestins in Breast Cancer,
Jorge R. Pasqualini
Epidemiology and Treatment of Benign Breast Disease: Effect of Progestins on Breast Disease,
Regine Sitruk-Ware and Genevieve Plu-Bureau
Other Indications
Therapeutic Use of Progestins: Practical Recommendations,
Regine Sitruk-Ware
Metabolic Effects of Progestins
The Effect of Progestins on Plasma Lipids,
Matti J. Tikkanen
Hormonal Replacement Therapy and Glucose Metabolism in Postmenopausal Women,
Sven O. Skouby
Antiprogestins
Antiprogestins in Clinical Practice,
Irving M. Spitz and Ann Robbins
Pharmacokinetics
Pharmacokinetics of Progesterone Administered Orally and Parenterally,
Frank Z. Stanczyk
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