Developmental and reproductive toxicology : a practical approach

著者

書誌事項

Developmental and reproductive toxicology : a practical approach

edited by Ronald D. Hood

CRC, Taylor & Francis, 2006

2nd ed

タイトル別名

Handbook of developmental toxicology

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注記

First ed. published in 1997 under title: Handbook of developmental toxicology

Includes bibliographical references and index

内容説明・目次

内容説明

Completely revised and updated, Developmental and Reproductive Toxicology: A Practical Approach, Second Edition draws together valuable information typically scattered throughout the literature, plus some not previously published, into one complete resource. In addition to the traditional aspects of developmental toxicity testing, the book covers evaluating and interpreting data. Originally titled Handbook of Developmental Toxicology, the second edition's new name reflects significant changes in its content and scope. New coverage in the Second Edition: Genomics and proteomics Tests for endocrine disruptors Testing for male and female reproductive toxicity Extensive treatment of the significance, reliability, and interpretation of developmental and reproductive toxicity data Toxicity testing in neonatal and juvenile animals Postnatal developmental milestones FDA perspective on risk assessment Extensive glossaries of developmental defect terminology Previous books on this subject have largely been academically oriented and not intended to guide the practicing developmental or reproductive toxicologist. Useful and informative, this book blends the theoretical foundation with insights gained from hands-on experience. It includes tables of comparative developmental milestones - both pre- and postnatal, glossaries of descriptive terms used in developmental toxicity evaluation, and both US and international regulatory guidelines. Bridging the gap between theory and application, this is a handy single-source of essential information to use in planning, conducting, and interpreting studies.

目次

PRINCIPLES AND MECHANISMS Principles of Developmental Toxicology Revisited, R.D. Hood Experimental Approaches to Evaluate Mechanisms of Developmental Toxicity, E.M. Faustman, J.M. Gohlke, R.A. Ponce, T.A. Lewandowski, M.R. Seeley, S.G. Whittaker, and W.C. Griffith Pathogenesis of Abnormal Development, L.B. Fawcett and R.L. Brent Maternally-Mediated Effects on Development, R.D. Hood and D.B. Miller Paternally-Mediated Effects on Development, B.F. Hales and B. Robaire Comparative Features of Vertebrate Embryology, J.M. DeSesso HAZARD AND RISK ASSESSMENT AND REGULATORY GUIDANCE Developmental Toxicity Testing - Methodology, R.W. Tyl and M.C. Marr Nonclinical Juvenile Toxicity Testing, M.J. Beck, E.L. Padgett, C.J. Bowman, D.T. Wilson, L.E. Kaufman, B.J. Varsho, D.G. Stump, M.D. Nemec, and J.F. Holson Significance, Reliability, and Interpretation of Developmental and Reproductive Toxicity Study Findings, J. Holson, M.D. Nemec, D.G. Stump, L.E. Kaufman, P. Lindstroem, and B.J. Varsho Testing for Reproductive Toxicity, R.M. Parker The U.S. EPA Endocrine Disruptor Screening Program: In Vitro and In Vivo Mammalian Tier I Screening Assays, S.C. Laws, T.E. Stoker, J.M. Goldman, V. Wilson, L.E. Gray, Jr., and R.L. Cooper Role of Xenobiotic Metabolism in Developmental and Reproductive Toxicity, A.P. Kulkarni Use of Toxicokinetics in Developmental and Reproductive Toxicology, P.J. Wier Cellular, Biochemical, and Molecular Techniques in Developmental Toxicology, B.D. Abbott, M.B. Rosen, and G. Held Functional Genomics and Proteomics in Developmental and Reproductive Toxicology, O. Spiegelstein, R.M. Cabrera, and R.H. Finnell In Vitro Methods for the Study of Mechanisms of Developmental Toxicology, C. Harris and J.M. Hansen Statistical Analysis for Developmental and Reproductive Toxicologists, J.J. Chen Quality Concerns for Developmental and Reproductive Toxicologists, K.D. Barrowclough and K.L. Reed Perspectives on the Developmental and Reproductive Toxicity Guidelines, M.S. Christian, A.M. Hoberman, and E.M. Lewis Human Studies - Epidemiologic Techniques in Developmental and Reproductive Toxicology, B. Kallen Developmental and Reproductive Toxicity Risk Assessment for Environmental Agents, C.A. Kimmel, G.L. Kimmel, and S.Y. Euling Principles of Risk Assessment-FDA Perspective, T.F.X. Collins, R.L. Sprando, M.E. Shackelford, M.F. Gruber, and D.E. Morse APPENDICES A. Terminology of Anatomical Defects B. Books Related to Developmental and Reproductive Toxicology C. Postnatal Developmental Milestones

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