Animal models in toxicology

Author(s)

Bibliographic Information

Animal models in toxicology

edited by Shayne C. Gad

CRC/Taylor & Francis, c2007

2nd ed

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Note

Includes bibliographical references and index

Contents of Works

  • Introduction / Shayne C. Gad
  • The mouse
  • The rat
  • The hamster
  • The guinea pig
  • The rabbit
  • The ferret
  • The dog
  • Primates
  • The minipig
  • Alternative species / Shayne C. Gad
  • Clinical pathology of laboratory animals / Robert L. Hall
  • Model selection and scaling / Shayne C. Gad
  • Susceptibility factors / Shayne C. Gad
  • Laws and regulations governing animal care and use in research / Shayne C. Gad

Description and Table of Contents

Description

Reflecting more than a decade's worth of changes, Animal Models in Toxicology, Second Edition is a practical guide to the common statistical problems encountered in toxicology and the methodologies that are available to solve them. The book presents a historical review of the use of animal models and an overview of broad considerations of metabolism and relevance used in toxicology. Individual chapters covering the eight major species used in toxicology and experimental biology form the core of the book. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provide an excellent introductory "course" along with guidance to the literature for more detailed understanding. The book goes on to make the case for a range of species not commonly used for safety assessment studies but which may provide useful alternative models for some specific endpoints. The chapter authors discuss special considerations regarding the evaluation and interpretation of the clinical pathology of the eight major model species as well as how to select a model species and how to extrapolate the results to humans. They detail potential pitfalls and situations that cause either human or model to be significantly more sensitive than the other or totally irrelevant to each other. The book concludes with an overview of the increasingly complex laws and regulations that govern how laboratory animals are obtained, maintained, and utilized, and an appendix that provides a quick guide to commercial sources of laboratory animals.

Table of Contents

Introduction, S.C. Gad The Mouse Toxicology, S.C. Gad Pathology, C.H. Frith, D.G. Goodman, and B.G. Boysen Metabolism, S.C. Gad The Rat Toxicology, M.D. Johnson Pathology, S.C. Gad Metabolism, S.C. Gad The Hamster Toxicology, S.C. Gad Pathology, F.G. Hess Metabolism, S.C. Gad The Guinea Pig Toxicology, S.C. Gad Pathology, J.C. Peckham Metabolism, S.C. Gad The Rabbit Toxicology, C.M. Salamon and K.M. MacKenzie Pathology, J.C. Peckham Metabolism, S.C. Gad The Ferret Toxicology, D.E. McLain Pathology, S. Chandra Metabolism, S.C. Gad The Dog Toxicology, G.C. Haggerty Pathology, J.C. Peckham and R.W. Thomassen Metabolism, S.C. Gad Primates Toxicology, M.D. Walker, J.K. Nelson, and J.C. Bernal Pathology, G.B. Baskin Metabolism, S.C. Gad The Minipig Toxicology, S.C. Gad Pathology, Z. Dincer and O. Svendsen Metabolism, M.T. Skaanild Alternative, S.C. Gad Clinical Pathology of Laboratory Animals, R.L. Hall Model Selection and Scaling, S.C. Gad Susceptibility Factors, S.C. Gad Laws and Regulations Governing Animal Care and Use in Research, S.C. Gad Appendix: Commercial Sources of Laboratory Animals, S.C. Gad Index

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