Animal models in toxicology
著者
書誌事項
Animal models in toxicology
CRC/Taylor & Francis, c2007
2nd ed
並立書誌 全1件
大学図書館所蔵 全3件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
収録内容
- Introduction / Shayne C. Gad
- The mouse
- The rat
- The hamster
- The guinea pig
- The rabbit
- The ferret
- The dog
- Primates
- The minipig
- Alternative species / Shayne C. Gad
- Clinical pathology of laboratory animals / Robert L. Hall
- Model selection and scaling / Shayne C. Gad
- Susceptibility factors / Shayne C. Gad
- Laws and regulations governing animal care and use in research / Shayne C. Gad
内容説明・目次
内容説明
Reflecting more than a decade's worth of changes, Animal Models in Toxicology, Second Edition is a practical guide to the common statistical problems encountered in toxicology and the methodologies that are available to solve them. The book presents a historical review of the use of animal models and an overview of broad considerations of metabolism and relevance used in toxicology. Individual chapters covering the eight major species used in toxicology and experimental biology form the core of the book. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provide an excellent introductory "course" along with guidance to the literature for more detailed understanding. The book goes on to make the case for a range of species not commonly used for safety assessment studies but which may provide useful alternative models for some specific endpoints. The chapter authors discuss special considerations regarding the evaluation and interpretation of the clinical pathology of the eight major model species as well as how to select a model species and how to extrapolate the results to humans. They detail potential pitfalls and situations that cause either human or model to be significantly more sensitive than the other or totally irrelevant to each other. The book concludes with an overview of the increasingly complex laws and regulations that govern how laboratory animals are obtained, maintained, and utilized, and an appendix that provides a quick guide to commercial sources of laboratory animals.
目次
Introduction, S.C. Gad The Mouse
Toxicology, S.C. Gad
Pathology, C.H. Frith, D.G. Goodman, and B.G. Boysen
Metabolism, S.C. Gad The Rat
Toxicology, M.D. Johnson
Pathology, S.C. Gad
Metabolism, S.C. Gad The Hamster
Toxicology, S.C. Gad
Pathology, F.G. Hess
Metabolism, S.C. Gad
The Guinea Pig
Toxicology, S.C. Gad
Pathology, J.C. Peckham
Metabolism, S.C. Gad The Rabbit
Toxicology, C.M. Salamon and K.M. MacKenzie
Pathology, J.C. Peckham
Metabolism, S.C. Gad The Ferret
Toxicology, D.E. McLain
Pathology, S. Chandra
Metabolism, S.C. Gad The Dog
Toxicology, G.C. Haggerty
Pathology, J.C. Peckham and R.W. Thomassen
Metabolism, S.C. Gad Primates
Toxicology, M.D. Walker, J.K. Nelson, and J.C. Bernal
Pathology, G.B. Baskin
Metabolism, S.C. Gad The Minipig
Toxicology, S.C. Gad
Pathology, Z. Dincer and O. Svendsen
Metabolism, M.T. Skaanild
Alternative, S.C. Gad
Clinical Pathology of Laboratory Animals, R.L. Hall
Model Selection and Scaling, S.C. Gad
Susceptibility Factors, S.C. Gad
Laws and Regulations Governing Animal Care and Use in Research, S.C. Gad
Appendix: Commercial Sources of Laboratory Animals, S.C. Gad Index
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