Structural proteomics and its impact on the life sciences

著者

書誌事項

Structural proteomics and its impact on the life sciences

editors, Joel L. Sussman, Israel Silman

World Scientific, c2008

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注記

Includes bibliographical references and index

収録内容

  • The importance of target selection strategies in structural biology / Enrique E. Abola and Raymond C. Stevens
  • The impact of structural proteomics on macromolecular structure databases / James D. Watson and Janet M. Thornton
  • The impact of 3D structures on a protein knowledgebase : from proteins to systems / Ursula Hinz and Amos Bairoch
  • Bioinformatics of protein function / Arthur M. Lesk ... [et al.]
  • Comparative modeling in structural genomics / John Moult
  • The contribution of structural proteomics to understanding the function of hypothetical proteins / Michael D. Suits ... [et al.]
  • Intrinsically disordered proteins / Peter Tompa
  • Metalloproteins : structure, conservation and prediction of metal binding sites / Marvin Edelman ... [et al.]
  • The impact of protein expression methodologies on structural proteomics / A. Chesneau, H. Yumerefendi and D.J. Hart
  • Protein complexes assembly by multi-expression in bacterial and eukaryotic hosts / Christophe Romier
  • The impact of structural proteomics on the prediction of protein-protein interactions / Christina Kiel and Luis Serrano
  • Cryo-electron microscopy in the era of structural proteomics / Alasdair C. Steven and David M. Belnap
  • On NMR-based structural proteomics / Thomas Szyperski
  • Structural proteomics in relation to signaling pathways / Florence Bedez, Arnaud Poterszman and Dino Moras
  • The impact of structural proteomics on drug design / Yuan-Ping Pang
  • Structural proteomics of emerging viruses : the examples of SARS-CoV and other coronaviruses / Rolf Hilgenfeld ... [et al.]
  • High-throughput technologies for structural biology : the protein structure initiative perspective / Andrzej Joachimiak
  • European structural proteomics : a perspective / Susan Daenke, E. Yvonne Jones and David I. Stuart
  • Structural genomics and structural proteomics : a global perspective / Lucia Banci ... [et al.]
  • Policies in structural genomics/structural proteomics

内容説明・目次

内容説明

The role played by structural proteomics in the first decade of the 21st century is equivalent to that played by the Human Genome Project in the last decade of the 20th century. The development of high-throughput technologies that permit the solution of hundreds of 3D structures of individual proteins, protein-protein complexes and protein-drug complexes, just by one laboratory in a single year, will provide a knowledge base which will change the face of structural biology. This will have an immediate influence on medicinal chemistry and molecular pharmacology, as well as an increasing impact on such disciplines as neurobiology, developmental biology, immunology and molecular medicine.This book presents a state-of-the-art overview of the structural proteomics field, ranging from policy issues related to funding and goals, through the high-throughput procedures for protein production, to the solution of the structures of proteins and higher-order entities, via a multidisciplinary approach involving molecular biology, X-ray crystallography, NMR and electron microscopy, as well as bioinformatics analysis. This is the first book to provide such a comprehensive coverage of a rapidly evolving field.

目次

  • Intrinsically Disordered Proteins (P Tompa)
  • Impact of Structural Proteomics on Protein Crystallography (A Joachimiak)
  • NMR in Structural Proteomics (R Kaptein & G Montelione)
  • The Contribution of Structural Proteomics to Understanding the Function of Hypothetical Proteins (M D Suits et al.)
  • Impact of SP on CASP and Vice Versa (J Moult)
  • The Impact of 3D Structures on a Protein KnowledgeBase. From Proteins to Systems (U Hinz & A Bairoch)
  • The Impact of Structural Proteomics on Macromolecular Structure Databases (D Dimitropoulos et al.)
  • SP of Metalloproteins (M Edelman & V Sobolev)
  • Impact of Protein Expression Methodologies on SP (D Hart)
  • Bioinformatics and SP (A Lesk)
  • Cryo-Electron Microscopy in the Era of Structural Proteomics (A C Steven & D M Belnap)
  • SP of Complexes (T Perakis & C Romier)
  • Structural Proteomics of Emerging Pathogens (R Hilgenfeld et al.)
  • Strategies in SP (R Stevens)
  • Impact of Structural Proteomics on Prediction of Protein-Protein Interactions (C Kiel & L Serrano)
  • SP and Drug Design (Y-P Pang)
  • SP in Relation to Signaling Pathways (D Moras)
  • Policies in Structural Genomics/Structural Proteomics (J Norvell et al.).

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