Genetics of hypertension
著者
書誌事項
Genetics of hypertension
（Handbook of hypertension / series editors: W. H. Birkenhäger and J. L. Reid, v. 24）
Elsevier, 2007
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Classic and modern tools of genetics have been applied to hypertension research for some 20 years. This volume in the "Handbook of Hypertension" series aims to go beyond a simple summary of discoveries and provides a critical commentary on many controversial issues. It will be particularly useful for clinician scientists at all stages of their careers, graduate students and post-doctoral scientists as well as all those interested in cardiovascular medicine and research throughout the entire spectrum from bench to bedside. As in every relatively young area of research, the initial excitement over the early positive observations has not always been confirmed by subsequent larger studies with greater statistical power. Issues related to current recommendations on design of studies and their analysis are therefore included. Pharmacogenetics and pharmacogenomics have been the subjects of many debates in recent years and are of particular importance in hypertension as life-long treatments, frequently with multiple drugs are given to millions of people world-wide. A critical appraisal of this controversial topic is provided.
Several chapters on experimental genetics of hypertension with a special focus on physiological genomics are also included.
目次
Overview and introduction. Genetic epidemiology of hypertension and its complications. Meta-analyses in genetics: examples from the renin-angiotensin system. Gene-gene and gene-environment interactions in normotensive and hypertensive populations. Genetic studies of inherited hypertension in the rat. Genetic studies of inherited hypertension in the mouse. Transgenic rats and hypertension. Gene targeting in mice to study blood pressure regulation. Monogenic syndromes leading to hypertension and hypotension. Candidate genes within the renin-angiotensin system in essential hypertension. Genetics of pre-eclamsia. Genetics of stroke. Adducin gene as a paradigm for functional studies. Genome scans in hypertension. Comparative genome analysis. Attaching physiology to the genome. Pharmacogenetics and pharmacogenomics in cardiovascular medicine. Gene therapy for hypertension: fact or fiction?.
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