Geriatric bioscience : the link between aging and disease

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Geriatric bioscience : the link between aging and disease

David Hamerman ; foreword by Robert N. Butler

Johns Hopkins University Press, 2007

  • : hard

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Geriatric bioscience : the link between aging & disease

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Includes bibliographical references (p. [227]-279) and index

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Description and Table of Contents

Description

It is increasingly important for physicians who treat older persons, and for researchers on aging, to understand how molecular biology informs clinical expressions of aging and age-related conditions such as osteoporosis, diabetes, osteoarthritis, frailty, cancer, and dementia. Dr. David Hamerman translates basic scientific concepts into precepts of clinical practice and sheds light on the links among biology, natural aging, longevity, and disease. Exploring the connections between disease and the science behind it, Geriatric Bioscience addresses how mechanisms of inflammation, cytokine expression, and stress responses influence disease and how preventive gerontology in the practice of medicine could compress morbidity. Hamerman also discusses cutting-edge therapies such as cyclo-oxygenases, bisphosphonates, statins, cytokine inhibitors, and hormone therapies. Examining the science of geriatrics and converting its concepts into clinical applications, this groundbreaking work provides clinicians and researchers with a solid foundation for a greater understanding of the diagnosis, treatment, and prevention of age-related diseases as well as recommendations for promoting healthy aging.

Table of Contents

Foreword by Robert N. Butler Preface 1. The Emergence and Future of Geriatrics 2. An Introduction to Concepts of Molecular Biology 3. Aging I. Trends in the Aging of the Population II. What Is Aging? Can We Distinguish betweenAging and Disease? III. Mechanisms of Aging IV. Longevity: Genetics of Extended Life Span or Risk for Adverse Events 4. Interrelations of Certain Aging-related Conditions I. Cytokines, Inflammation, and Responses to Stress II. Atherosclerosis: Risk Factors for Cardiovascular Disease III. The Metabolic Syndrome and Type 2 Diabetes IV. Osteoporosis V. Osteoarthritis VI. Frailty and Related Conditions: Anorexia, Sarcopenia, Exercise VII. Cancer VIII. Alzheimer Disease 5. Interactive Therapies Significant for an Aging Population I. Cyclooxygenases II. Statins III. Bisphosphonates IV. Thiazolidinediones and Peroxisome Proliferatoractivated Receptor V. Cytokine Inhibitors as a Landmark for Newer Anti-inflammatory Therapies VI. Hormonal Therapies 6. Preventive Gerontology I. The Compression or Expansion of Morbidity? II. Healthy Lifestyle Practices III. "Successful Aging" Epilogue Glossary References Index

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