Gene and cell therapy : therapeutic mechanisms and strategies

著者

書誌事項

Gene and cell therapy : therapeutic mechanisms and strategies

edited by Nancy Smyth Templeton

CRC Press, c2009

3rd ed

大学図書館所蔵 件 / 全2件

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

Since the publication of the second edition of this book in 2004, gene therapy and cell therapy clinical trials have yielded some remarkable successes and some disappointing failures. Now in its third edition, Gene and Cell Therapy: Therapeutic Mechanisms and Strategies assembles many of the new technical advances in gene delivery, clinical applications, and new approaches to the regulation and modification of gene expression. New Topics Covered in this Edition: Gene and Cell Therapies for Diabetes and Cardiovascular Diseases Clinical Trials Human Embryonic Stem Cells Tissue Engineering Combined with Cell Therapies Novel Polymers Relevant Nanotechnologies SiRNA Therapeutic Strategies Dendrimer Technologies Comprised of contributions from international experts, this book begins with a discussion of delivery systems and therapeutic strategies, exploring retroviral vectors and adenovirus vectors, as well as other therapeutic strategies. The middle section focuses on gene expression and detection, followed by an examination of various therapeutic strategies for individual diseases, including hematopoietic disorders, cardiovascular conditions, cancer, diabetes, cystic fibrosis, neurological disorders, and childhood-onset blindness. The final section discusses recent clinical trials and regulatory issues surrounding the new technology. This compendium is assembled by noted molecular biologist and biochemist Nancy Smyth Templeton. Baylor College of Medicine and several other institutions have used Dr. Templeton's non-viral therapeutics in clinical trials for the treatment of lung, breast, head and neck, and pancreatic cancers, as well as Hepatitis B and C. She continues to work at the forefront of research in gene and cell therapies. Her contributions, as well as those contained in this volume, are sure to advance the state of the art of these revolutionary life-saving technologies.

目次

Delivery Systems and Therapeutic Strategies Retroviral Vectors for Cell and Gene Therapy, A. Schambach, T. Maetzig, and C. Baum Production of Retroviral Vectors: From the Producer Cell to the Final Product, P.E. Cruz, A.S. Coroadinha, T. Rodrigues, and H. Hauser Adenovirus Vectors for Gene Therapy, N.R. Hackett and R.G. Crystal Modified Adenoviruses for Gene Therapy, J.N. Glasgow, A. Hemminki, and D.T. Curiel Helper-Dependent Adenoviral Vectors for Gene Therapy, N. Brunetti-Pierri and P. Ng Adeno-Associated Virus and AAV Vectors for Gene Delivery, B.J. Carter, H. Burstein, and R.W. Peluso Therapeutic Gene Transfer with Replication-Defective Herpes Simplex Viral Vectors, D. Wolfe, W.F. Goins, A. Frampton, M. Mata, D.J. Fink, and J.C. Glorioso Oncolytic Viruses for Treatment of Cancer, M. Raki, M. Rajecki, D. Kirn, and A. Hemminki Lentiviral Vectors, J.M. Felder III and R. Sutton Vaccinia Viral Vectors, J.A. McCart and D.L. Bartlett Baculovirus-Mediated Gene Transfer: An Emerging Universal Concept, K.J. Airenne, A.J. Mahoenen, O.H. Laitinen, and S. Yla-Herttuala Bacterial Vector in Gene Therapy, M.-S. Dai and G. Vassaux Redox-Responsive Polymer-Based Gene Delivery Systems, D. Oupicky, Y.-Z. You, and D.S. Manickam Polymers and Dendrimers for Gene Delivery in Gene Therapy, I.F. Uchegbu, C. Dufes, P.L. Kan, and A.G. Schatzlein Receptor-Targeted Polyplexes for DNA and siRNA Delivery, A. Philipp and E. Wagner Electroporation of Plasmid-Based Vaccines and Therapeutics, R. Draghia-Akli and A.S. Khan Magnetofection: Using Magnetic Particles and Magnetic Force to Enhance and to Target Nucleic Acid Delivery, F. Scherer and C. Plank Biolistic and Other Needle-Free Delivery Systems, M.A.F. Kendall Optimization of Nonviral Gene Therapeutics, N. Smyth Templeton Photochemical Internalization: A Technology for Efficient and Site-Specifi c Gene Delivery, A. Bonsted, A. Hogset, and K. Berg Interactions in Macromolecular Complexes Used as Nonviral Vectors for Gene Delivery, R. Podgornik, D. Harries, J. DeRouchey, H.H. Strey, and V.A. Parsegian Other Therapeutic Strategies In vivo Applications of Morpholino Oligonucleotides, J.S. Isenberg, W.A. Frazier, and D.D. Roberts Antisense Oligonucleotide-Based Therapeutics, C.F. Bennett, E. Swayze, R. Geary, L. Tillman, and G. Hardee Development of RNAi Therapeutics, A.R. de Fougerolles Suicide Gene Therapy, N. Ballian, B.W. O'Malley Jr., and F.C. Brunicardi Selectable Markers for Gene Therapy, J.-P. Gillet, C. Kimchi-Sarfaty, S. Shinar, T. Licht, C. Lee, P. Hafkemeyer, C.A. Hrycyna, I. Pastan, and M.M. Gottesman Embryonic Stem Cells and Their Application in Regenerative Medicine and Tissue Engineering,.D. Evans and J.M. Polak Polymeric Nano- and Microparticles for the Delivery of Antisense Oligonucleotides and siRNA, E. Fattal and G. De Rosa Gene Expression and Detection Deliberate Regulation of Therapeutic Transgenes, N. Vilaboa and R. Voellmy Monitoring Gene and Cell Therapies in Living Subjects with Molecular Imaging Technologies, S. Ray, S. Biswal, and S.S. Gambhir Nonviral Genome Modification Strategies for Gene Therapy: Transposon, Integrase, and Homologous Recombination Systems, L.E. Woodard and M.P. Calos Disease Targets and Therapeutic Strategies Hematopoietic Progenitor Cells, K.-Y.K. Lin, O. Sirin, and M.A. Goodell Gene Therapy for Hematopoietic Disorders,.M. Kang, M.E. Horwitz, and H.L. Malech Use of Genetically Modified Stem Cells in Experimental Gene Therapies, T.P. Zwaka Cardiovascular Gene and Cell Therapy, K. Oka Gene Therapy for Cancer, K. Brand Molecular Therapy for Type 1 and Type 2 Diabetes, S.L. Samson, V. Yechoor, and L. Chan Progress toward Gene Therapy for Cystic Fibrosis, R.S. Everett and L.G. Johnson Gene Therapy for Neurological Diseases, W.J. Bowers, S. de Silva, and H.J. Federoff Principles of Gene Therapy for Inborn Errors of Metabolism, J.A. Wolff and C.O. Harding RNA Interference-Based Gene Therapy Strategies for the Treatment of HIV Infection, L. Scherer and J.J. Rossi Cutaneous Gene Transfer: Cell and Gene Therapy of Skin and Systemic Disorders, W. Buitrago and D.R. Roop Gene Therapy for Childhood Onset Blindness, M.C. Canver and J. Bennett DNA Vaccines, J. Yan and D.B. Weiner Immunoisolation for CNS Cell Therapy, D.F. Emerich and C.G. Thanos Clinical Trials and Regulatory Issues Cardiovascular Gene Therapy, J. Tongers, J. Roncalli, and D.W. Losordo Gene Therapy for the Treatment of Cancer: From Laboratory to Bedside, G. Dotti, B. Savoldo, F. Okur, R.F. Rousseau, and M.K. Brenner p53 Tumor Suppressor Opens Gateways for Cancer Therapy, M.-S. Dai, J.R. Gallegos, and H. Lu Recombinant Adenoviral-p53 Agent for Treatment of Cancers, Z. Peng, Q. Yu, and J. Zhu Gene Marking Studies of Hematopoietic Cells, C.M. Bollard, S.K. Tey, M.K. Brenner, and H.E. Heslop Regulatory Aspects of Gene Therapy, S.L. Simek and L. Bi Index

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