Mouse models of developmental genetic disease

Author(s)

• Krauss, Robert S.

Bibliographic Information

Mouse models of developmental genetic disease

edited by Robert S. Krauss

（Current topics in developmental biology / edited by A.A. Moscona, Alberto Monroy, v. 84）

Academic, 2008

1st ed

Note

Includes bibliographical references and index

Description and Table of Contents

Description

Approximately three percent of newborn humans have congenital anomalies with significant cosmetic and/or functional consequences. Much of our ability to understand what has gone awry in these birth defects rests with development of animal models for them; the mouse has emerged as the model organism of choice for these studies. This volume reviews mouse models of specific developmental genetic diseases, including neural tube defects; cleft lip and/or palate; congenital heart disease; ciliopathies; hereditary deafness and others to provide conceptual insight into congenital anomalies generally. The interplay between clinical observation and murine model systems is expected to yield deep insight into mammalian developmental processes and the emergence of effective preventive and/or therapeutic strategies.

Table of Contents

1) Comprehensive Phenotyping of Genetically Modified Mice to Identify New Target Disease Indications Author: Sandra Engle 2) Modeling the Repair Process in Multiple Sclerosis Author: H. Arnett 3) Mouse Genetic Models for Individualized Symptomatology of Cancer and Infectious Disease Author: P. Demant 4) New Rodent Models for Obesity, Diabetes, and Metabolic Syndrome Author: R. Peterson 5) Mouse Models of Huntingdon's Disease Author: L. Menalled, M. Chesselet 6) Mouse Models for Ocular Disease Author: L. Molday 7) Hyperlipidemia-Induced Atherosclerosis Author: A. Daugherty 8) Mouse Models for Mitochondrial Disease Authors: D. Wallace

by "Nielsen BookData"

• NCID: BA88497734
• ISBN:
  • 9780123744548
• Country Code: us
• Title Language Code: eng
• Text Language Code: eng
• Place of Publication: San Diego, Calif. ; London
• Pages/Volumes: xv, 493 p., [18] p. of plates
• Size: 24 cm
• Classification:
  • DC22 : 616.027333
• Subject Headings:
  • LCSH : Diseases -- Animal models
  • LCSH : Mice as laboratory animals
• Parent Bibliography ID:
  • BA00305828