Aminomethylenemalonates and their use in heterocyclic synthesis
著者
書誌事項
Aminomethylenemalonates and their use in heterocyclic synthesis
（Advances in heterocyclic chemistry / ed. by Alan R. Katritzky, v. 54）
Academic Press, c1992
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注記
Includes indexes
内容説明・目次
内容説明
This volume surveys the chemistry and heterocyclic syntheses of aminomethylenemalonates and their cyclic sters. Early reviews in this field merely touched on certain aspects of the related chemistry. This is the first in-depth systematic treatment of the subject. The material is of particular importance in medicinal chemistry as derivatives of aminomethylene malonates are key intermediates in the synthesis of antimalarial agents. The literature reviewed has led to the discovery of nalidixic acid and its derivatives, norfloxacin and ciprofloxacin, as well as the new quinolones that are active against AIDS-related Legionella spp.
目次
- Work in the 19th century
- structure of aminomethylenemalonates. Part 1 Syntheses: sytheses of kialkly 1-aminoalkylidenemalonates
- syntheses of alkylidene 1-aminoalkylidenemalonates
- syntheses of 2-azacycloalkylidenemalonates. Part 2 Cyclization of 1-aminoalkylidenemalonates: cyclization of dialkyl aminoalkylidenemalonates
- cyclization of alkylidene aminomethylenemalonates
- cyclization of azacycloalkylidenemalonates
- further ring closure. Part 3 Other reaction of aminomethylenemalonates: reactions of dialkyl 1-aminoalkylidenemalonates
- reactions of alkylidene aminomethylenemalonates
- reaction of 2-azacycloalkylidenemalonates
- miscellaneous methods
- recent research appendix.
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