Aminomethylenemalonates and their use in heterocyclic synthesis
Author(s)
Bibliographic Information
Aminomethylenemalonates and their use in heterocyclic synthesis
(Advances in heterocyclic chemistry / ed. by Alan R. Katritzky, v. 54)
Academic Press, c1992
Related Bibliography 2 items
Available at 3 libraries
  Aomori
  Iwate
  Miyagi
  Akita
  Yamagata
  Fukushima
  Ibaraki
  Tochigi
  Gunma
  Saitama
  Chiba
  Tokyo
  Kanagawa
  Niigata
  Toyama
  Ishikawa
  Fukui
  Yamanashi
  Nagano
  Gifu
  Shizuoka
  Aichi
  Mie
  Shiga
  Kyoto
  Osaka
  Hyogo
  Nara
  Wakayama
  Tottori
  Shimane
  Okayama
  Hiroshima
  Yamaguchi
  Tokushima
  Kagawa
  Ehime
  Kochi
  Fukuoka
  Saga
  Nagasaki
  Kumamoto
  Oita
  Miyazaki
  Kagoshima
  Okinawa
  Korea
  China
  Thailand
  United Kingdom
  Germany
  Switzerland
  France
  Belgium
  Netherlands
  Sweden
  Norway
  United States of America
Note
Includes indexes
Description and Table of Contents
Description
This volume surveys the chemistry and heterocyclic syntheses of aminomethylenemalonates and their cyclic sters. Early reviews in this field merely touched on certain aspects of the related chemistry. This is the first in-depth systematic treatment of the subject. The material is of particular importance in medicinal chemistry as derivatives of aminomethylene malonates are key intermediates in the synthesis of antimalarial agents. The literature reviewed has led to the discovery of nalidixic acid and its derivatives, norfloxacin and ciprofloxacin, as well as the new quinolones that are active against AIDS-related Legionella spp.
Table of Contents
- Work in the 19th century
- structure of aminomethylenemalonates. Part 1 Syntheses: sytheses of kialkly 1-aminoalkylidenemalonates
- syntheses of alkylidene 1-aminoalkylidenemalonates
- syntheses of 2-azacycloalkylidenemalonates. Part 2 Cyclization of 1-aminoalkylidenemalonates: cyclization of dialkyl aminoalkylidenemalonates
- cyclization of alkylidene aminomethylenemalonates
- cyclization of azacycloalkylidenemalonates
- further ring closure. Part 3 Other reaction of aminomethylenemalonates: reactions of dialkyl 1-aminoalkylidenemalonates
- reactions of alkylidene aminomethylenemalonates
- reaction of 2-azacycloalkylidenemalonates
- miscellaneous methods
- recent research appendix.
by "Nielsen BookData"