Hepatobiliary and pancreatic carcinogenesis in the hamster
著者
書誌事項
Hepatobiliary and pancreatic carcinogenesis in the hamster
Springer, c2009
大学図書館所蔵 全6件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
- 巻冊次
-
ISBN 9784431877721
目次
- 1 General Information(The Syrian Hamster as an Experimental Animal;Surgical Instruments;Anesthesia of the Laboratory Hamster ほか)
- 2 Experimental Carcinogenesis in the Hamster(Hamster Models of Biliary Carcinoma;Biliary Carcinomas Induced in the Hamster;Biliary Inflammation and Biliary Carcinogenesis ほか)
- 3 Cancer Lines and Biliary Epithelial Cell Lines(Establishment of Transplantable Biliary Cancer Lines;Establishment of Biliary Epithelial Cell Lines from the Hamster)
「BOOKデータベース」 より
内容説明・目次
- 巻冊次
-
ISBN 9784431877721
内容説明
Malignant neoplasms occurring in the biliary tract and pancreas remain a therap- tic challenge. The mechanism of carcinogenesis as well as the growth and spread of these tumors is still poorly understood, making the development of rational tre- ment strategies difficult. In order to improve the clinical results achieved by sur- cal or other medical treatment of such malignant tumors, the establishment of an experimental animal model is critical. For this purpose, attempts were made to induce carcinoma experimentally in the biliary tree and finally an animal model using the hamster was established in 1994 at our laboratory. Because the tumor in this model mimicked the characteristics of human tumors, a series of experimental investigations were conducted to clarify the pathological characteristics of biliary carcinoma, the genetic alterations during biliary carcinogenesis, and the relationship between biliary inflammation and c- cinogenesis. The chemopreventive effects on the occurrence of biliary carcinoma were also successfully examined. In addition, in vitro studies led to the establi- ment of transplantable biliary cancer cell lines and biliary epithelial cell lines by utilizing the hamster model. This monograph represents the collective efforts in hepato-biliary and pancreatic disease research over the past 20 years. I hope that this monograph will be a source of useful knowledge for basic researchers as well as for clinicians involved in the care of patients with hepato-biliary and pancreatic neoplasms. Takashi Kanematsu, M.D., Ph.D.
目次
General Information.- The Syrian Hamster as an Experimental Animal.- Surgical Instruments.- Anesthesia of the Laboratory Hamster.- Fundamental Surgical Techniques.- Experimental Carcinogenesis in the Hamster.- Hamster Models of Biliary Carcinoma.- Biliary Carcinomas Induced in the Hamster.- Biliary Inflammation and Biliary Carcinogenesis.- Spontaneous Biliary Carcinogenesis.- Modification of Biliary Carcinogenesis.- Chemoprevention of Biliary Carcinogenesis.- Hamster Model of an Intraductal Papillary Mucinous Neoplasm (IPMN) of the Pancreas.- Chemoprevention of Pancreatic Carcinogenesis.- Cancer Lines and Biliary Epithelial Cell Lines.- Establishment of Transplantable Biliary Cancer Lines.- Establishment of Biliary Epithelial Cell Lines from the Hamster.
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