Genomics and pharmacogenomics in anticancer drug development and clinical response
著者
書誌事項
Genomics and pharmacogenomics in anticancer drug development and clinical response
(Cancer drug discovery and development)
Humana Press, c2008
- : hbk
- : ebk
大学図書館所蔵 全2件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response provides the most comprehensive body of knowledge available on the role of genetic and genomic variation in the individualization of drug therapies in cancer patients. As a consequence of the intrinsic chromosomal and genetic instability of the tumor genome, it is generally believed that tailoring of chemotherapy in cancer - tients might be achieved by molecular analysis of patient tumor DNA. In addition, to reduce the toxicity risk of patients, the tumor DNA information should be in- grated with the available data on polymorphic drug-metabolizing enzyme and tra- porter genes mediating the exposure of patients to active drugs and/or their active metabolites. The chapters of this book clearly show how DNA information from both the host (germline) and the tumor should be taken into account for rational selection of drug therapies in cancer patients, an aspect that received little attention, despite its importance. The availability of new molecular approaches to the selection of drug therapy is an emerging need, because the traditional approach based on the evaluation of patient and tumor characteristics is clearly far from optimal. Many treated patients do not experience signi?cant bene?ts from the treatment, while they often experience moderate to severe toxicities. In addition, the development and clinical use of novel molecularly targeted agents (alone or in combination with classical cytotoxic therapy) requires the und- standing of the molecular features of the tumors and the identi?cation of tumor markers of response.
目次
pharmacoGENOMICS, ANTICANCER DRUG DISCOVERY, AND RESPONSE Book editor: Federico Innocenti, M.D., Ph.D. Genomic experimental approaches in oncology Toward the realisation of the promise of microarrays in oncology Neil Winegarden Cell based models to identify genetic variants contributing to anticancer drug response M. Eileen Dolan Proteomic analysis in cancer patients Kazuyuki Nakamura MicroRNAs and discovery of new targets Gozoh Tsujimoto Pharmacogenomics of the National Cancer Institute's 60 tumor cell panel David G. Covell Use of single nucleotide polymorphism array for tumor aberrations in gene copy numbers Kwong-Kwok Wong Pharmacogenomics of toxicity and response of chemotherapy Concordance between tumor and germline DNA Sharon Marsh Epidermal growth factor receptor mutations and sensitivity to selective kinase inhibitors in human lung cancer Jeffrey Settleman 3. BCR-ABL mutations and imatinib resistance in chronic myeloid leukemia patients Mark Litzow Role of thymidylate synthase gene variations in colorectal cancer patients Heinz-Josef Lenz Thiopurines in the treatment of childhood acute lymphoblastic leukemia and genetic variants in the thiopurine S-methyltransferase gene Martin Stanulla The impact of polymorphisms on the clinical outcomes of monoclonal antibody therapy against hematologic malignancies Dong Hwan Kim DNA repair and mitotic check point genes as potential predictors of chemotherapy response in non-small-cell lung cancer Rafael Rosell Dihydropyrimidine dehydrogenase (DPYD) gene polymorphism: portrait of a serial killer. Gerard Milano Impact of UDP-glucuronosyltransferase 1A haplotypes on irinotecan treatment Kimie Sai Microarray profiling in breast cancer patients Lan Guo 11. Role of the folate pathway and the thymidylate synthase genes in pediatric acute lymphoblastic leukemia treatment response Richard Aplenc Pharmacogenomics in clinical drug development in oncology Pharmacogenomics in drug development: an pharmaceutical industry perspective Tal Zaks Identification of a pharmacogenomic biomarker classifiers in cancer drug development Richard Simon Toxicogenomics application to oncology drug development Teresa Lettieri Strategies to identify pharmacogenomic biomarkers: candidate gene, pathway-based, and genome-wide approaches Xifeng Wu
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