Concerning the origin of malignant tumours
著者
書誌事項
Concerning the origin of malignant tumours
The Company of Biologists , Cold Spring Harbor Laboratory Press, 2008, c2007
- タイトル別名
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Zur Frage der Entstehung maligner Tumoren
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注記
Includes bibliographical references (p. 81-82)
内容説明・目次
内容説明
Written almost a hundred years ago, Theodor Boveri's Zur Frage der Entstehung maligner Tumoren has had a momentous impact on cancer research. In it he argues that malignancy arises as a consequence of chromosomal abnormalities and that multiplication is an inherent property of cells. With astonishing prescience, Boveri predicts in this monograph the existence of tumor suppressor mechanisms and is perhaps the first to suggest that hereditary factors (genes) are linearly arranged along chromosomes. This new translation by Sir Henry Harris, Regius Professor of Medicine Emeritus at Oxford University and former Editor-in-Chief of Journal of Cell Science, includes extensive annotations in which he discusses the relevance of Boveri's views today. It is essential reading for all cancer researchers, as well as those interested in the history of cytogenetics and cell biology.
目次
I. Introduction II. Some observations from experimental cytology III. Relevance to the study of tumours IV. The explanatory value of the hypothesis V. Consideration of some objections VI. Conclusion References
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