Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets

著者

書誌事項

Mechanistic toxicology : the molecular basis of how chemicals disrupt biological targets

Urs A. Boelsterli

Informa Healthcare, c2009

2nd ed

大学図書館所蔵 件 / 全4件

この図書・雑誌をさがす

注記

Originally published: Boca Raton : CRC Press, 2007

Includes bibliographical references and index

内容説明・目次

内容説明

A thorough understanding of cellular and molecular mechanisms involved in the individual expression of toxic effects provides an important tool for assessment of human health risk. New aspects, major advances, and new areas in molecular and cellular biology and toxicology demand updated sources of information to elucidate the functional mechanics of human toxicology. Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological Targets, Second Edition retains the accessible format of the original to present the general principles that link xenobiotic-induced toxicity with the molecular pathways that underlie these toxic effects. Extensively illustrated, this book forms a conceptual bridge between multiple events at the molecular level and the determinants of toxicity at the physiological and cellular level. Specific examples of drugs, environmental pollutants, and other chemicals are carefully chosen to illustrate and highlight the fundamental mechanisms of toxicity at different toxicokinetic and toxicodynamic levels. The book includes references and review articles at the end of each chapter, as well as boxed text for relevant review information on biological, biochemical, molecular, and toxicological background. Linking molecular pathways to more general biomedical contexts, the author ensures that the reader is not lost in the details and instead receives a broad understanding of the processes underlying xenobiotic toxicity. New in the Second Edition Updated chapters Types of toxic responses Disruption of signal transduction by xenobiotics Disruption of mitochondrial function Novel mechanisms derived from systems toxicology

目次

Introduction, Types of Toxic Responses, Organ-Selective Toxicity, Cellular Transport and Selective Accumulation of Potentially Toxic Xenobiotics, Bioactivation of Xenobiotics to Reactive Metabolites, Xenobiotic-Induced Oxidative Stress: Cell Injury, Signaling, and Gene Regulation, Disruption of Cellular Calcium Homeostasis, Mechanisms of Necrotic and Apoptotic Cell Death, Impairment of Cell Proliferation and Tissue Repair, Covalent Binding of Reactive Metabolites to Cellular Macromolecules, Immune Mechanisms, Cytokine-Mediated Toxicity, Specific Inactivation of Enzymes and Other Proteins, Interactions of Xenobiotics with Ion Transporters, Nuclear Receptor-Mediated Toxicity, Activation or Disruption of Cellular Signal Transduction by Xenobiotics, Disruption of Mitochondrial Function and Mitochondria-Mediated Toxicity, Novel Mechanisms Derived from Systems Toxicology, Index

「Nielsen BookData」 より

詳細情報

ページトップへ