Regulation of gene expression by small RNAs

Author(s)

Bibliographic Information

Regulation of gene expression by small RNAs

edited by Rajesh K. Gaur and John J. Rossi

CRC Press, c2009

  • : hard

Available at  / 5 libraries

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Note

Includes bibliographical references and index

Contents of Works

  • MicroMining : computational approaches to microRNA discovery / Adam Grundhoff
  • Animal microRNA gene prediction / Ola Snøve and Pål S̄trom
  • A suite of resources for the study of microRNA ontology and function / Praveen Sethupathy, Molly Megraw, and Artemis G. Hatzigeorgiou
  • Regulation of translation and mRNA stability by Hfq-binding small RNAs in Escherichia coli / Hiroji Aiba
  • Mechanisms by which microRNAs regulate gene expression in animal cells / Yang Yu and Timothy W. Nilsen
  • The microRNAs of Caenorhabditis elegans / Mona J. Nolde and Frank J. Slack
  • Isolation and characterization of small RNAs in Caenorhabditis elegans / Chisato Ushida and Yusuke Hokii
  • MicroRNA tales in fly development / Utpal Bhadra ... [et al.]
  • RNA interference and microRNAs in zebra fish / Alex S. Flynt, Elizabeth J. Thatcher, and James G. Patton
  • Biogenesis and function of plant microRNAs / Zoltan Havelda
  • Endogenous small RNA pathways in Arabidopsis / Manu Agarwal, Julien Curaba, and Xuemei Chen
  • How to assay microRNA expression : a technology guide / Mirco Castoldi, Vladimir Benes, and Martina U. Muckenthaler
  • Methods to quantify microRNA gene expression / Lori A. Neely
  • Regulation of alternative splicing by microRNAs / Rajesh K. Gaur
  • Recent progress in polymerase II-mediated intronic microRNA expression systems / Shi-Lung Lin and Shao-Yao Ying
  • MicroRNA-based RNA polymerase II expression vectors for RNA interference in mammalian cells / Anne B. Vojtek, Kwan-Ho Chung, Paresh D. Patel, and Dvid L.Turner
  • Transgenic RNAi : a fast and low-cost approach to reverse genetics in mammals / Linghua Qiu and Zuoshang Xu
  • Symphony of AIDS : a microRNA-based therapy / Yoichi R. Fujii
  • MicroRNAs and cancer : connecting the dots / Sumedha D. Jayasena
  • Mammalian transcriptional gene silencing by small RNAs / Daniel H. Kim and John J. Rossi
  • Regulation of gene expression by RNA-mediated transcriptional gene silencing / Kevin V. Morris

Description and Table of Contents

Description

New Findings Revolutionize Concepts of Gene Function Endogenous small RNAs have been found in various organisms, including humans, mice, flies, worms, fungi, and bacteria. Furthermore, it's been shown that microRNAs acting as cellular rheostats have the ability to modulate gene expression. In higher eukaryotes, microRNAs may regulate as much as 50 percent of gene expression. Regulation of Gene Expression by Small RNAs brings together the pioneering work of researchers who discuss their work involving a wide variety of small RNA regulatory pathways in organisms ranging from bacteria to humans. In addition to exploring the biogenesis and processing of these regulatory RNAs, they also consider the functional importance of these pathways in host organisms. Assisting current and future researchers, this unique groundbreaking work - Provides a suite of cutting-edge resources for the study of microRNA ontology and function Includes a technology guide for those seeking to assay microRNA expression Explores the mechanisms by which microRNAs regulate gene expression in animal cells, including the regulation of gene expression by RNA-mediated transcriptional gene silencing Discusses a fast and low-cost approach for reversing genetic influences in mammals Looks at breakthroughs in the use of microRNA-based therapy for HIV and cancer This volume captures the essence of the breadth and excitement surrounding the newly discovered regulatory roles of small RNAs. The powerful new approach in the study of gene function described in this text is leading to some remarkable findings that have the potential to revolutionize our understanding of genetic function and the treatment of diseases otherwise considered intractable.

Table of Contents

IDENTIFICATION AND CHARACTERIZATION OF MICRORNAs. Experimental Approaches. Computational Approaches. STRUCTURE-FUNCTION ANALYSIS. Biosynthesis of MicroRNAs. Processing of MicroRNAs. MICRORNAs in DEVELOPMENT. Plants. C. elegans. Drosophila. Zebrafish. MICRORNAs AND CANCER. MICRORNAs AND VIRUSES. APPLICATIONS. Gene Regulation/Functional Genomics/Therapeutics.

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