Platinum and other heavy metal compounds in cancer chemotherapy : molecular mechanisms and clinical applications
著者
書誌事項
Platinum and other heavy metal compounds in cancer chemotherapy : molecular mechanisms and clinical applications
（Cancer drug discovery and development）
Humana Press, c2009
- : e-book
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Cisplatin, the first member of the family of platinum-containing chemotherapeutic agents, was discovered by Barnett Rosenberg in 1965 and approved by the FDA for marketing in 1978. After 30 years of use in the clinic, cisplatin remains a central element of many treatment regimens. Cisplatin is still an irreplaceable component of a regimen that produces high cure rates in even advanced nonseminomatous germ-cell cancers, and is widely used in the treatment of ovarian cancers and other gynecologic cancers, head and neck, and numerous other tumor types. The development of carboplatin has reduced some of the adverse events associated with cisplatin treatment, and the introduction of the DACH platinum compound oxaliplatin has broadened the spectrum of activity of the platinums to include gastro-intestinal cancers, especially colorectal cancer. The clinical importance of this family of drugs continues to drive investigation into how these drugs work and how to improve their efficacy and reduce their toxicity. The papers in this volume were presented in Verona, Italy, during the tenth International Symposium on Platinum Coordination Compounds in Cancer Chemotherapy. The symposium was jointly organized by the Department of Oncology of the Mater Salutis Hospital - Azienda Sanitaria Locale 21 of the Veneto Region - and by the Department of Medicine and Public Health, Section of Pharmacology, the University of Verona. They reflect the vitality of this field and the increasing use of new molecular and cell biologic, genetic, and biochemical tools to identify approaches to further improve their use.
目次
Platinum chemotherapy: an oncologic success story Lawerence H. Einhorn Platinum compounds in clinical development Hilary Calvert Satraplatin: overview Cristiana Sessa Satraplatin in prostate cancer Cora Sternberg New formulations Roman Perez-Soler Novel drug delivery systems: AP5346 Stephen B. Howell CTR1 as a determinant of platinum drug transport Stephen B. Howell ATP7B regulates intracellular sequestration of Pt drugs Rouhi Safaei Molecular alterations of oxaliplatin-resistant cell exhibiting accumulation defects Paola Perego How to overcome cisplatin resistance through proton pump inhibitors Stefano Fais Multiple mechanisms of resistance to cisplatin in cancer cells Michael Gottsman Platinum drug damage to DNA and nucleosomes: recognition/repair and cell-response mechanisms Stephen J. Lippard Molecular rationale to improve platinum selectivity Maurizio D'Incalci Recognition and processing of platinum drugs-DNA adducts Stephen G. Chaney Platinum drugs and DNA repair: lessons from the NCI-60 panel and clinical correlates Jacques Robert Effects of platinated compounds in signal transduction: role of interaction with other drugs Godefridus J. Peters Platinum drugs as radio-sensitizer Silvia Formenti Head and Neck cancer Lisa Licitra Non-colorectal cancer Florian Lordick Colorectal cancer Andrea Bonetti New drugs for the management of chemotherapy-induced nausea and vomiting Matti Aapro Breast cancer Luca Gianni Ovarian cancer Franco Muggia Cancer of the uterus Paul Hoskins Lung cancer Giuseppe Giaccone Heavy metal compounds in cancer chemotherapy: positive findings Gianni Sava, Heavy metal compounds in cancer chemotherapy: negative findings Jan Schellens Neurotoxicity Guido Cavalletti Anemia and myelosuppression Fabio Benedetti Platinum drugs and the children with cancer Riccardo Riccardi Allergic reactions Eleni Andreopoulou Optimizing dose using patient characteristics Etienne Chatelut The real impact of intraperitoneal chemotherapy in ovarian cancer Franco Muggia IP Therapy - Where do we go from here Stephen B Howell
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