Essential concepts in toxicogenomics

著者

    • Mendrick, Donna L.
    • Mattes, William B.

書誌事項

Essential concepts in toxicogenomics

edited by Donna L. Mendrick, William B. Mattes

（Methods in molecular biology / John M. Walker, series editor, 460）

Humana Press, c2008

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

The field of toxicogenomics is moving rapidly, so it is impossible at the timeofthiswritingtocompileaclassicmethodstextbook.Instead,wechose to identify experts in all aspects of this field and challenged them to write reviews, opinion pieces, and case studies. This book covers the main areas important to the study and use of toxicogenomics. Chapter 1 speaks to the convergenceofclassicapproachesalongsidetoxicogenomics.Chapter2deals withtheusefulnessoftoxicogenomicstoidentifythemechanismoftoxicity. Chapter3callsattentiontotheissuesthataffectthequalityoftoxicogenomics experiments, as well as the implications of using microarrays as diagnostic devices. The need for appropriate statistical approaches to genomic data is discussed in Chapter 4, and Chapters 5 and 6 describe the use of genomic datatobuildtoxicogenomicmodelsandprovideinsightsfromtheapproaches oftwocompanies.Theimportanttopicofstoringthedatageneratedinsuch experiments and the correct annotation that must accompany such data is considered in Chapter 7. The discussion in Chapter 8 speaks to the use of toxicogenomicstoidentifyspeciessimilaritiesanddifferences.Chapters9and 10dealwiththeuseofgenomicstoidentifybiomarkerswithinthepreclinical andclinicalarenas. Biomarkerswillonlybeusefulifthecommunityatlarge acceptsthemasmeaningful.Consortiaareimportanttodrivethisfunction,and Chapter11discussescurrenteffortsinthisarea.Lastbutnotleast,Chapter12 presentsaperspectiveontheregulatoryimplicationsoftoxicogenomicdataand someofthehurdlesthatcanbeseeninitsimplicationinGLPstudies.Although thisbooktendstofocusonpharmaceuticals,theissuesfacingtoxicologyare sharedbythechemicalmanufacturers,thetobaccoindustry,andtheirregulators. We want to thank our contributors for their generous time and energy in providingtheirinsights.Sadly,wemustnotetheunexpectedpassingofone ofourauthors,Dr.JosephHackettoftheFDA.Joe'scontributionservesasa testimonytohisaccomplishmentsinthisfield,andhisinsightwillbemissed intheyearstocome.

目次

Toxicogenomics and Classical Toxicology: How to Improve Prediction and Mechanistic Understanding of Human Toxicity Donna L. Mendrick Use of Traditional Endpoints and Gene Dysregulation to Understand Mechanisms of Toxicity: Toxicogenomics in Mechanistic Toxicology Wayne R. Buck, Jeffrey F. Waring, Eric A. Blomme. Quality Control of Microarray Assays for Toxicogenomic and In Vitro Diagnostic Applications Karol L. Thompson and Joseph Hackett Role of Statistics in Toxicogenomics Michael Elashoff Predictive Toxicogenomics in Preclinical Discovery Scott A. Barros and Rory B. Martin In Vivo Predictive Toxicogenomics Mark W Porter Bioinformatics: Databasing and Gene Annotation Lyle D. Burgoon and Timothy R. Zacharewski Microarray Probe Mapping and Annotation in Cross-Species Comparative Toxicogenomics John N Calley, William B Mattes, and Timothy Ryan Toxicogenomics in Biomarker Discovery Marc F. DeCristofaro and Kellye K. Daniels From Pharmacogenomics to Translational Biomarkers Donna L. Mendrick Public Consortium Efforts in Toxicogenomics William B. Mattes Applications of Toxicogenomics to Nonclinical Drug Development - Regulatory Science Considerations Frank D. Sistare and Joseph J. DeGeorge

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