Therapeutic applications of RNAi : methods and protocols
著者
書誌事項
Therapeutic applications of RNAi : methods and protocols
（Methods in molecular biology / John M. Walker, series editor, 555）（Springer protocols）
Humana Press, c2009
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
The phenomenon of RNA interference has rapidly moved from groundbreaking scientific discovery to promising therapeutic approach. However, even as RNAi-based drugs enter the clinic, significant challenges remain, particulary in the area of delivery. Therapeutic Applications of RNAi provides detailed protocols in key areas of current focus, including testing of delivery vehicles, identification of appropriate model systems, and evaluation of the effects of RNAi in vivo. Produced by a team of internationally renowned authors, the volume describes the therapeutic applications of RNAi and potential pitfalls in oncology, viral infections and CNS disease, using a variety of delivery methods, including liposomes, peptide-based nanoparticles, polycationic polymers, and viral vehicles. Written in the highly successful Methods in Molecular Biology (TM) series format, the chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls.
Authoritative and cutting-edge, Therapeutic Applications of RNAi is an ideal guide for scientists attempting to solve the numerous challenges in this field and revolutionize the treatment of disease.
目次
1. Development and Application of a Dual-Purpose Nanoparticle Platform for Delivery and Imaging of siRNA in Tumors
Zdravka Medarova, Mohanraja Kumar, Shu-wing Ng, and Anna Moore
2. Targeted Gene Silencing into Solid Tumors with Electrically Mediated siRNA Delivery
Muriel Golzio, Laurent Mazzolini, Aurelie Paganin-Gioanni, and Justin Teissie
3. Liposomal siRNA for Ovarian Cancer
Lingegowda S. Mangala, Hee Dong Han, Gabriel Lopez-Berestein, and Anil K. Sood
4. Therapeutic Applications of RNAi for Silencing Virus Replication
Ralph A. Tripp and Stephen Mark Tompkins
5. RNAi in the Malaria Vector, Anopheles gambiae
Flaminia Catteruccia and Elena A. Levashina
6. RNAi Using a Chitosan/siRNA Nanoparticle System: in vitro and in vivo Applications
Morten Ostergaard Andersen, Kenneth Alan Howard, and Jorgen Kjems
7. Lentiviral and Adeno-Associated Vector-Based Therapy for Motor Neuron Disease through RNAi
Chris Towne and Patrick Aebischer
8. Studying Autoimmunity by in vivo RNA Interference
Stephan Kissler
9. Transcriptional Gene Silencing Using Small RNAs
Daniel H. Kim and John J. Rossi
10. Alternative Splicing as a Therapeutic Target for Human Diseases
Kenneth J. Dery, Veronica Gusti, Shikha Gaur, John E. Shively, Yun Yen, and Rajesh K. Gaur
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