Cell cycle control : new research

著者

    • Leroy, Nathan H.
    • Fournier, Noah T.

書誌事項

Cell cycle control : new research

Nathan H. Leroy and Noah T. Fournier, editors

Nova Biomedical Books, c2008

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注記

Includes bibliographical references and indexes

内容説明・目次

内容説明

This book provides leading edge research on a cell cycle, which is an ordered and highly controlled set of events that leads to cell growth and proliferation. Cell cycle progression is driven by changes in the substrate specificity and subcellular localisation of cyclin-dependent kinases (Cdks), which in turn are modulated by a collection of cyclins, Cdk-activating and Cdk-inhibiting kinases, and Cdk inhibitors (CDKIs). Regulation of the cell cycle is critical for the normal development of multicellular organisms and dysregulation of cell cycle could lead to cancer, a disease where normal cell growth and behaviour are lost. Cell cycle regulation is tightly controlled by both synthesis and degradation of short-lived proteins, such as cyclins and CDKIs, and degradation of these proteins is mainly mediated by the ubiquitin-dependent proteasome pathway.

目次

  • Preface
  • Insulin-Like Growth Factor Regulation of Cell Proliferation
  • The Beginning of the MicroRNA Era for Cell Cycle Control
  • TGFss: A Unique and Powerful Negative Regulator of the Cell Cycle in Human Myeloid Leukaemia Cells
  • Transforming Growth Factor Beta and Cell Cycle Regulation
  • Transcription Factor C/EBPa and its Effects on Cell Cycle Regulation
  • The Non-Hemodynamic Effect of Angiotensin II in Renal Fibrogenesis
  • Cyclin-Dependent Kinase Inhibitors and Aging
  • The Role and Predictive Power of Cell Cycle Checkpoints in Aging, Cardiovascular, Cancer, and Neurodegenerative Diseases
  • The Role of Cell Cycle Control Genes in the Pathogenesis of Human Hematological Neoplasms
  • Cell Cycle Control in Drosophila
  • Cell Cycle Control of Mammals during the Embryonic Period and Recent Research
  • An Innovative Educational Module for Community Pharmacists
  • Cell Cycle Arrest by Dietary Chemopreventive Agents
  • Chromatin: The Biophysical Approach to Elucidating Structure and Function
  • Index.

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