Pharmaceutical biotechnology
著者
書誌事項
Pharmaceutical biotechnology
（Advances in experimental medicine and biology, v. 655）
Springer Science+Business Media , Landes Bioscience, c2009
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
Pharmaceutical Biotechnology is a unique compilation of reviews addressing frontiers in biologicals as a rich source for innovative medicines. This book fulfills the needs of a broad community of scientists interested in biologicals from diverse perspectives-basic research, biotechnology, protein engineering, protein delivery, medicines, pharmaceuticals and vaccinology. The diverse topics range from advanced biotechnologies aimed to introduce novel, potent engineered vaccines of unprecedented efficacy and safety for a wide scope of human diseases to natural products, small peptides and polypeptides engineered for discrete prophylaxis and therapeutic purposes. Modern biologicals promise to dramatically expand the scope of preventive medicine beyond the infectious disease arena into broad applications in immune and cancer treatment, as exemplified by anti-EGFR receptors antibodies for the treatment of breast cancer. The exponential growth in biologicals such as engineered proteins and vaccines has been boosted by unprecedented scientific breakthroughs made in the past decades culminating in an in-depth fundamental understanding of the scientific underpinnings of immune mechanisms together with knowledge of protein and peptide scaffolds that can be deliberately manipulated. This has in turn led to new strategies and processes. Deciphering the human, mammalian and numerous pathogens' genomes provides opportunities that never before have been available-identification of discrete antigens (genomes and antigenomes) that lend themselves to considerably improved antigens and monoclonal antibodies, which with more sophisticated engineered adjuvants and agonists of pattern recognition receptors present in immune cells, deliver unprecedented safety and efficacy. Technological development such a nanobiotechnologies (dendrimers, nanobodies and fullerenes), biological particles (viral-like particles and bacterial ghosts) and innovative vectors (replication-competent attenuated, replication-incompetent recombinant and defective helper-dependent vectors) fulfill a broad range of cutting-edge research, drug discovery and delivery applications. Most recent examples of breakthrough biologicals include the human papilloma virus vaccine (HPV, prevention of women genital cancer) and the multivalent Pneumoccocal vaccines, which has virtually eradicated in some populations a most prevalent bacterial ear infection (i.e., otitis media). It is expected that in the years to come similar success will be obtained in the development of vaccines for diseases which still represent major threats for human health, such as AIDS, as well as for the generation of improved vaccines against diseases like pandemic flu for which vaccines are currently available. Furthermore, advances in comparative immunology and innate immunity revealed opportunities for innovative strategies for ever smaller biologicals and vaccines derived from species such as llama and sharks, which carry tremendous potential for innovative biologicals already in development stages in many pharmaceutical companies. Such recent discoveries and knowledge exploitations hold the promise for breakthrough biologicals, with the coming decade. Finally, this book caters to individuals not directly engaged in the pharmaceutical drug discovery process via a chapter outlining discovery, preclinical development, clinical development and translational medicine issues that are critical the drug development process.
The authors and editors hope that this compilation of reviews will help readers rapidly and completely update knowledge and understanding of the frontiers in pharmaceutical biotechnologies.
目次
1. Translational Medicine-a Paradigm Shift in Modern Drug Discoveryand Development: The Role of Biomarkers
Mark Day, J. Lynn Rutkowski and Giora Z. Feuerstein 2. Natural Products in Drug Discovery: Present Status and Perspectives
Gabriella Molinari 3. Protein Pharmaceuticals: Discovery and Preclinical Development
Davinder S. Gill 4. The Role of Nanobiotechnology in drug discovery
Kewal K. Jain 5. Conotoxin Venom Peptide Therapeutics
Richard J. Lewis 6. Shark novel antigen receptors-the next generation of biologic therapeutics?
Caroline Barelle, Davinder Gill and Keith Charlton 7. Immune Interventions of Human Diseases through Toll-Like Receptors
Cevayir Coban, Ken J. Ishii and Shizuo Akira 8. Genome-Based Vaccine Development: A Short Cut for the Future
Danilo Gomes Moriel, Maria Scarselli, Laura Serino, Marirosa Mora, Rino Rappuoli
and Vega Masignani 9. The Antigenome: From Protein Subunit Vaccines to Antibody Treatments of Bacterial Infections?
Carmen Giefing, Eszter Nagy and Alexander von Gabain 10. HSV as a vector in vaccine development and gene therapy
Peggy Marconi, Rafaela Argnani, Alberto L. Epsteinand Roberto Manservigi 11. Virus-Like Particles as a Vaccine Delivery System: Myths and Facts
Polly Roy and Rob Noad 12. Applications of Bacterial Ghosts in Biomedicine
Petra Lubitz, Ulrike Beate Mayr and Werner Lubitz 13. Immune Modulators with Defined Molecular Targets: Cornerstone to Optimize Rational Vaccine Design
Thomas Ebensen and Carlos A. Guzman 14. Innovative Approaches to Develop Prophylactic and Therapeutic Vaccines against HIV/AIDS
Aurelio Cafaro, Iole Macchia, Maria Teresa Maggiorella, Fausto Titti and Barbara Ensoli 15. New Strategies to Overcome the Drawbacks of Currently Available Flu Vaccines
Epifanio Fichera, Diana Felnerova, Robert Mischler, Jean-Francois Viret and ReinhardGlueck
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