Computational protein-protein interactions

著者

    • Nussinov, Ruth
    • Schreiber, Gideon

書誌事項

Computational protein-protein interactions

edited by Ruth Nussinov and Gideon Schreiber

CRC Press, c2009

大学図書館所蔵 件 / 全5件

この図書・雑誌をさがす

注記

Includes bibliographical references and index

収録内容

  • Basic principles of protein-protein interaction / Joël Janin
  • Low-resolution recognition factors determine major characteristics of the energy landscape in protein-protein interaction / Ilya A. Vakser
  • The molecular architecture of protein-protein binding sites / Eric J. Sundberg
  • Mapping protein function by combinatorial mutagenesis / Gábor Pál and Sachdev S. Sidhu
  • The association of protein-protein complexes / Gideon Schreiber
  • Computational simulations of protein-protein and protein-nucleic acid association / Georgi V. Pachov, Razif R. Gabdoulline, and Rebecca C. Wade
  • Computational design of protein-protein interactions / Julia M. Shifman
  • Protein-protein docking / Howook Hwang, Brian Pierce, and Zhiping Weng
  • Prediction of protein interaction sites / Yanay Ofran
  • Predicting molecular interactions in structural proteomics / Irina Kufareva and Ruben Abagyan
  • Rearrangements and expansion of the domain content in proteins frequently increase the protein connectivity in the protein-protein interaction network / Inbar Cohen-Gihon, Roded Sharan, and Ruth Nussinov
  • Intrinsically disordered proteins and their recognition functions / Vladimir N. Uversky ... [et al.]
  • Identification of druggable hot spots on proteins and in protein-protein interfaces / Dmitri Beglov ... [et al.]
  • Designing protein-protein interaction inhibitors / Matthieu Montes

内容説明・目次

内容説明

Often considered the workhorse of the cellular machinery, proteins are responsible for functions ranging from molecular motors to signaling. The broad recognition of their involvement in all cellular processes has led to focused efforts to predict their functions from sequences, and if available, from their structures. An overview of current research directions, Computational Protein-Protein Interactions examines topics in the prediction of protein-protein interactions, including interference with protein-protein interactions and their design. Explores Computational Approaches to Understanding Protein-Protein Interactions Outlining fundamental and applied aspects of the usefulness of computations when approaching protein-protein interactions, this book incorporates different views of the same biochemical problem from sequence to structure to energetics. It covers protein-protein interaction prediction and dynamics, design, drug design for inhibition, and uses for the prediction of function. The text provides general chapters that overview the topic and also includes advanced material. The chapters detail the complexity of protein interaction studies and discuss potential caveats. Addresses the Next Big Problem in Molecular Biology While it is important to predict protein associations, this is a daunting task. Edited by two experts in the field and containing contributions from those at the forefront of research, the book provides a basic outline of major directions in computational protein-protein interactions research at the heart of functional genomics and crucial for drug discovery. It addresses the next big problem in molecular biology: how to create links between all the pieces of the cell jigsaw puzzle.

目次

Computational design of protein-protein interactions. Molecular Mimicry and Competitive Recruitment. Intrinsically unstructured proteins. The molecular architecture of protein-protein binding sites. Characteristic of protein-protein recognition. Protein-Protein Docking. Identification of hot spots within druggable binding regions. Hot-spot mimicry of ac cytokine receptor. Chaperone-related immune dysfunction. Recognition proteins of the innate immune system. Epitope mapping using combinatorial phage-display libraries. Identification of conserved protein complexes based on a model of protein network evolution. Interaction sites identified from sequences. Thermophilic Protein Complex Stabilized by Topological Interlinked. Protein interface recognition for structural proteomics. Strategies to search and design stabilizers of protein-protein interactions. Dynamics and allostery in protein-protein interactions.

「Nielsen BookData」 より

詳細情報

ページトップへ