Peptides : chemistry and biology

著者

• Sewald, Norbert
• Jakubke, Hans-Dieter

書誌事項

Peptides : chemistry and biology

Norbert Sewald and Hans-Dieter Jakubke

Wiley-VCH, c2009

2nd, rev. and updated ed

• : pbk

注記

First ed.: 2002

Includes bibliographical references and index

内容説明・目次

内容説明

Thoroughly updated, incorporating around 25 % new material, Sewald/Jakubke remains the only modern and scientifically up-to-date advanced textbook on peptide biochemistry, distilling the knowledge of hundreds of publications into a highly readable synopsis of this diverse field. The authors explain the broad fundamentals of peptide synthesis and structure, systematically addressing important families of biologically active peptides, and adopting an interdisciplinary approach that covers application areas in biotechnology, pharmaceutical science, and biomedicine. One major focus is on such "hot" research topics as pseudopeptides, peptidomimetics, and combinatorial synthesis. This new edition also features study questions for each learning unit, for easier self-study and classroom teaching.

目次

INTRODUCTION AND BACKGROUND FUNDAMENTAL CHEMICAL AND STRUCTURAL PRINCIPLES Definitions and Main Conformational Features of the Peptide Bond Building Blocks, Classification, and Nomenclature Analysis of the Covalent Structure of Peptides and Proteins Three-Dimensional Structure Methods of Structural Analysis BIOLOGY OF PEPTIDES Historical Aspects and Biological Functions Biosynthesis Selected Biologically Active Peptides PEPTIDE SYNTHESIS Principles and Objectives Protection of Functional Groups Peptide Bond Formation Racemization During Synthesis Solid-Phase Peptide Synthesis (SPPS) Biochemical Synthesis SYNTHESIS CONCEPTS FOR PEPTIDES AND PROTEINS Strategy and Tactics Solution Phase Synthesis (SPS) NEW: Solution Phase/Solid Phase-Hybrid Approaches Optimized Strategies on Polymeric Support Chemical Ligation Strategies SYNTHESIS OF SPECIAL PEPTIDES AND PEPTIDE CONJUGATES Cyclopeptides Cystine Peptides Glycopeptides Phosphopeptides Lipopeptides Sulfated Peptides PEPTIDE AND PROTEIN DESIGN, PSEUDOPEPTIDES, AND PEPTIDOMIMETICS Peptide Design Modified Peptides Peptidomimetics Pseudobiopolymers Macropeptides and De-Novo Design of Peptides and Proteins COMBINATORIAL PEPTIDE SYNTHESIS Parallel Synthesis Synthesis of Mixtures APPLICATION OF PEPTIDES AND PROTEINS NEW: General Production Strategies NEW: Improvement of the Therapeutic Potential Protein Pharmaceuticals Peptide Pharmaceuticals PEPTIDES IN PROTEOMICS NEW: Genome and Proteome NEW: Separation Methods NEW: Peptide and Protein Analysis in Proteomics NEW: Activity-Based Proteomics

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詳細情報

• NII書誌ID(NCID): BB00738516
• ISBN:
  • 9783527318674
• 出版国コード: gw
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Weinheim
• ページ数/冊数: xvi, 578 p.
• 大きさ: 25 cm
• 分類:
  • DC22 : 547.7
• 件名:
  • LCSH : Peptides