Therapeutic oligonucleotides
著者
書誌事項
Therapeutic oligonucleotides
（RSC biomolecular sciences）
RSC Pub., c2008
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注記
Includes bibliographical references and index
内容説明・目次
内容説明
This book provides a comprehensive overview of the development of therapeutic oligonucleotides for therapeutic applications, touching on a number of additional oligonucleotides including a number of small interfering RNAs currently in various phases of clinical development. Written by leading expert scientists from both academia and leading biotechnical companies, the authors provide a compelling update on current status of RNA interference with emphasis on fascinating topics including oligonucleotides: antisense oligonucleotides, ribozymes, siRNAs, decoy oligonucleotides and aptamers. This exceptional work will be a valid resource for researchers and students as well as academia, consultants and scientists.
目次
- Chapter 1: The Role of Backbone Modifications in Oligonucleotide-Based Strategies
- Chapter 2: Genasense (G3139): An Antisense Bcl-2 Oligodeoxyribonucleotide with Substantial Clinical Activity and a Complex Mechanism of Action
- Chapter 3: Antisense Morpholino Oligomers and Their Peptide Conjugates
- Chapter 4: Peptide-PNA Conjugates for Modulation of Gene Expression
- Chapter 5: Locked Nucleic Acid: Properties & Therapeutic Aspects
- Chapter 6: Immune Stimulatory Oligonucleotides
- Chapter 7: Decoy Oligonucleotides to Treat Inflammatory Diseases
- Chapter 8: AS1411: Development of an Anticancer Aptamer
- Chapter 9: Spielgelmer NOX-E36 for Renal Diseases
- Chapter 10: Strategies for the Delivery of Oligonucleotides In Vivo
- Chapter 11: Lipid-Mediated in vivo Delivery of Small Interfering RNAs
- Chapter 12: Vector-Mediated and Viral Delivery of Short Hairpin RNAs
- Chapter 13: Development of an RNAi Based Gene Therapy against HIV-1
- Chapter 14: RNA Based Therapies for Treatment of HIV Infection
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