Glycobiology research trends

著者

    • Powell, George
    • McCabe, Oliver

書誌事項

Glycobiology research trends

George Powell and Olivier McCabe, editors

Nova Biomedical Books, c2009

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注記

Includes bibliographical references and index

収録内容

  • Multidrug resistance protein 1 (MDR1) and glycosphingolipid biosynthesis / María Fabiana De Rosa and Clifford A. Lingwood
  • Sophisticated modes of sugar recognition by intracellular lectins involved in quality control of glycoproteins / Yukiko Kamiya ... [et al.]
  • Glyco-biosensors : properties, materials and applications / S. Cunningham, J. Gerlach and L. Joshi
  • Structure and activities of natural complex polysaccharides / Nicola Volpi and Francesca Maccari
  • CMP-N-acetylneuraminic acid synthetases and sialyltransferases from bacterial sources / Takeshi Yamamoto
  • Heparan sulfate D-glucosaminyl 3-O-sulfotransferases / Tomio Yabe and Nobuaki Maeda
  • Click chemistry in carbohydrate based drug development and glycobiology / Brendan L. Wilkinson ... [et al.]
  • Functional enzyme complex involved in HNK-1 carbohydrate biosynthesis / Yasuhiko Kizuka, Yasuhiro Tonoyama, and Shogo Oka
  • Protein-specific glycosylation : cis-controlling peptidic elements / Franz-Georg Hanisch
  • Activation of invariant Va819-Ja833 TCR a-bearing cells by stimulation with certain a-mannosylated glycolipids / Michio Shimamura

内容説明・目次

内容説明

Glycobiology is the study of the structure, biosynthesis and biology of saccharides that are widely distributed in nature and are essential components of all living things. This field combines expertise in both carbohydrate biochemistry and molecular biology. The ABC drug transporter, P glycoprotein or MDR1 is one such example discussed in this book. The relationship of glycosphingolipid (GSL) biosynthesis to the Pgp-mediated multiple drug resistance phenotype, and the role of MDR1 in lipid biosynthesis in particular is evaluated. The structure and activities of natural complex polysaccharides are also analysed. Specifically, heparin (Hep) as an anticoagulant and antithrombotic (macro)molecule and CS in the treatment of osteoarthritis is reviewed, and the GAG structure-function relationship, which has led to the discovery of novel drugs for the possible treatment of some serious diseases. The gene targeting analyses of certain enzymes, which revealed that the HNK-1 carbohydrate plays important roles in synaptic plasticity and memory function, is described as well. Recent work on the topic 'protein-specific glycosylation' is highlighted also, focusing on the primary structure of a protein which directly exerts a cis-control of the glycosylation event.

目次

  • Preface
  • Multidrug Resistance Protein 1 (MDR1) and Glycosphingolipid Biosynthesis
  • Glyco-Biosensors: Properties, Materials and Applications
  • Structure and Activities of Natural Complex Polysaccharides
  • CMP-N-acetylneuraminic Acid Synthetases and Sialyltransferases from Bacterial Sources
  • Heparan Sulfate D-glucosaminyl 3-O-sulfotransferases
  • Click Chemistry in Carbohydrate Based Drug Development and Glycobiology, pp. 57-102
  • Functional Enzyme Complex Involved in HNK-1 Carbohydrate Biosynthesis
  • Protein-specific Glycosylation: Cis-controlling Peptidic Elements
  • Activation of Invariant V819-J833 TCR 8-bearing Cells by Stimulation with certain 8-mannosylated glycolipids
  • Index.

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