Bone cancer : progression and therapeutic approaches
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Bibliographic Information
Bone cancer : progression and therapeutic approaches
Academic, 2010
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Includes bibliographical references and index
Description and Table of Contents
Description
The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research. This period of time has been marked by a number of key discoveries that have led to the opening up of entirely new areas for investigation as well as new therapies which combine surgery and biological therapeutic approaches.Bone is a common site of cancer metastases - cancer cells commonly develop in bone and spread to other organ systems through the bloodstream. For example, the incidence of bone metastases in breast and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic lung cancer. In clinical terms, bone metastases have substantial negative effects on a patient's quality of life and are a main cause of patient mortality. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for the medical and cancer research communities. This book provides, all in one resource, the most recent data on bone cancer development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases.
Table of Contents
Section 1: Introduction Genetic control, frequencies and epidemiology of bone cancers The incidence and progression of metastatic bone lesions Section 2: Bone microenvironment and bone cancer Bone microenvironment and tumor growth Osteoblast Differentiation and Cell Signalling Osteoclast Differentiation and FunctionCytokines in bone remodeling and bone tumors Proteases and bone tumors - therapeutic approaches Section 3: Bone markers Early bone metastasis Bone remodeling markers and bone cancer Proteomic of bone cancers Genomic Alterations in Bone Tumors Biology of bone tumors and new diagnostic tools Gene profiling of osteosarcoma Molecular pathology of osteosarcomaHistopathology of prostate and breast metastasesTechnical aspects: how do we best prepare bone samples for proper histological analysis?Section 4: Myeloma, odontogenic tumors and bone metastases Multiple myeloma bone diseasesOsteolytic lesionsBone metastases of prostatic cancer Bone metastases of breast cancer Section 5: Primary bone tumors Osteosarcoma and osteoblasts: diagnosis and therapy Ewing sarcoma family of tumors: diagnosis and therapyNon-surgical treatment of chondrosarcoma: diagnosis and therapyChondrosarcoma of bone: diagnosis and therapy Osteoclast-rich lesions of bone: diagnosis and therapy Section 6: Imaging of bone cancers Interventional Radiologic TechniquesImaging of bone metastases Diagnosis of bone metastases Section 7: Pain control in bone cancers Pain control with radiotherapyMechanisms and management of bone cancer pain Malignant skeletal painSection 8: New therapeutic advances of bone cancers Primary bone tumors and novel therapeutic approaches Cytokine gene therapy in bone remodeling BisphosphonatesMulti-targeted approachRANKL and targeted therapy Apoptosis and drug resistance
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