Genome stability and human diseases
著者
書誌事項
Genome stability and human diseases
(Subcellular biochemistry, 50)
Springer, c2010
大学図書館所蔵 全3件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, genomic instability is important in the development of cancer. This view is supported by the findings that aneuploidy, which results from chromosome instability, is one of the hallmarks of cancer cells. Chromosomal instability also underpins our fundamental principles of understanding tumourigenesis: It thought that cancer arises from the sequential acquisition of genetic alterations in specific genes. In this hypothesis, these rare genetic events represent rate-limiting 'bottlenecks' in the clonal evolution of a cancer, and pre-cancerous cells can evolve into neoplastic cells through the acquisition of somatic mutations.
This book is written by international leading scientists in the field of genome stability. Chapters are devoted to genome stability and anti-cancer drug targets, histone modifications, chromatin factors, DNA repair, apoptosis and many other key areas of research. The chapters give insights into the newest development of the genome stability and human diseases and bring the current understanding of the mechanisms leading to chromosome instability and their potential for clinical impact to the reader.
目次
Robert P. Fisher, Coming full circle: Cyclin-dependent kinases as anti-cancer drug targets. Stephen Rea, Histone modifications in normal development and disease. Thomas Costelloe and Noel F. Lowndes, Both chromatin assembly and signalling the end of DNA repair requires acetylation of histone H3 on lysine 56. David M. S. Pinto and Andrew Flaus, Structure and function of histone H2AX. Helmut Pospiech, Frank Grosse, and Francesca Pisani, The initiation step of eukaryotic DNA replication. Torsten Krude, Non-coding RNAs: New players in the field of eukaryotic DNA replication. Sokka Miiko, Parkkinen Sinikka, Helmut Pospiech, and Juhani E. Syvaoja, Function of TopBP1 in genome instability. Sandra Broderick, Kristina Rehmet, Claire Concannon, and Heinz-Peter Nasheuer, Eukaryotic single-stranded DNA binding proteins and genomic stability. Emmanuele Crespan, Alessandra Amoroso, and Giovanni Maga, DNA polymerases and mutagenesis in human cancers. Severine Cruet-Hennequart, Kathleen Gallagher, Anna M. Sokol, Sangamitra Villalan, Aine M. Prendergast, and Michael P. Carty, DNA polymerase h , a key protein in translesion synthesis in human cells. William C. Copeland, The Mitochondrial DNA Polymerase in Health and Disease. Macdara Glynn, Agnieszka Kaczmarczyk, Lisa Prendergast, Nadine Quinn, and Kevin F. Sullivan, Chromosome segregation and genome instability. N. I. Rechkunova and O. I. Lavrik, Nucleotide excision repair in higher eukaryotes: Mechanism of primary damage recognition in global genome repair. Michael R. Lieber, Jiafeng Gu, Haihui Lu, Noriko Shimazaki, and Albert G. Tsai, Nonhomologous DNA End Joining (NHEJ) and Chromosomal Translocations in Humans. Michael Boehringer and Lisa Wiesmuller, Fluorescence-based quantification of pathway-specific DSB repair activities: a powerful method for the analysis of genome destabilizing mechanisms. ChiaraMondello and A. Ivana Scovassi, Apoptosis: a way to prevent genome instability. Sarah Conmy and Heinz-Peter Nasheuer, The use of transgenic mice in cancer and genome stability research.
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