Recombinant antibodies for immunotherapy
著者
書誌事項
Recombinant antibodies for immunotherapy
Cambridge University Press, 2009
- : hbk
大学図書館所蔵 全1件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
Recombinant Antibodies for Immunotherapy provides a comprehensive overview of the field of monoclonal antibodies (mAbs), a market that has grown tremendously in recent years. Twenty-five articles by experienced and innovative authors cover the isolation of specific human mAbs, humanization, immunogenicity, technologies for improving efficacy, 'arming' mAbs, novel alternative Ab constructs, increasing half-lives, alternative concepts employing non-immunoglobulin scaffolds, novel therapeutic approaches, a market analysis of therapeutic mAbs, and future developments in the field. The concepts and technologies are illustrated by examples of recombinant antibodies being used in the clinic or in development. This book will appeal to both newcomers and experienced scientists in the field, biology and biotechnology students, research and development departments in the pharmaceutical industry, medical researchers, clinicians, and biotechnology investors.
目次
- Part I. Introduction: 1. Past, present and future of recombinant antibodies G. Winter
- Part II. Generation and Screening of Antibody Libraries: 2. Antibody libraries from naive V gene sources G. Beste and D. Lowe
- 3. Antibodies from IgM libraries V. Molkenthin and S. Knackmuss
- Part III. Transgenic Human Antibody Repertoires: 4. The generation and screening of synthetic antibody libraries I. Klagge
- 5. Therapeutic antibodies from xenoMouse transgenic mice A. Jakobovits
- 6. Transgenic chimeric antibodies A. Murphy
- Part IV. Humanised Antibodies: 7. Humanization of recombinant antibodies J. Saldanha
- 8. Immunogenicity assessment of antibody therapeutics P. Stas, J. Pletinckx, Y. Gansemans, and I. Lasters
- 9. In vitro screening for antibody immunogenicity F. Carr and M. Baker
- Part V. Antibody Effector Function: 10. Mechanisms of tumour cell killing by therapeutic antibodies R. Stewart and C. Webster
- 11. Optimization of Fc domains to enhance antibody therapeutics G. Lazar and A. Chamberlain
- 12. Glycoengineered therapeutic antibodies P. Brunker, P. Sondermann, and P. Umana
- Part VI. Arming Antibodies: 13. Monoclonal antibodies for the delivery of cytotoxic drugs D. King
- 14. Immunotherapy with radioimmune conjugates C. Kousparou and A. Epenetos
- 15. Immunotherapeutic antibody fusion proteins N. Courtenay-Luck and D. Jones
- Part VII. Antibody Fragments: 16. Alternative antibody formats F. Le Gall and M. Little
- 17. Single domain antibodies S. Muyldermans
- 18. Engineering of non-CDR loops in immunoglobulin domains F. Ruker and G. Wozniak-Knopp
- Part VIII. Antigen Binding Repertoires of Non-Immunoglobulin Proteins: 19. Alternative antibody scaffolds A. Plueckthun
- Part IX. Prolongation of Serum Half Life: 20. Polymer fusions to increase antibody half lives: PEGylation and other modifications S. Heywood and D. Humphreys
- 21. Extending antibody half-lives with albumin J. Andersen and I. Sandlie
- Part X. Current Therapeutic Antibodies and Novel Developments: 22. A stem cell-based platform for the discovery and development of anti-tumor therapeutic antibodies to novel targets J. Mather, C. Fieger, T. Liang, K. King, J. Li, P. Young, C. Beltejar, B. Potts, M. Licea, and D. Loo
- 23. Antibody directed enzyme prodrug therapy (ADEPT) H. Lowe, S. Sharma, and K. Bagshawe
- 24. Immune privilege and tolerance - therapeutic antibody approaches D. Forman, P. Ponath, D. Mehta, J. Ponte, J. Snyder, P. Rao, H. Waldmann, and M. Rosenzweig
- Part XI. Market Overview and Outlook: 25. Antibody therapeutics: business achievements and business outlook C. Bourrilly.
「Nielsen BookData」 より