Textbook of drug design and discovery
Author(s)
Bibliographic Information
Textbook of drug design and discovery
CRC Press, c2010
4th ed
- : hbk.
Available at / 4 libraries
-
No Libraries matched.
- Remove all filters.
Note
"Pharmacology and toxicology" -- at head of back cover title
Includes bibliographical references and index
Description and Table of Contents
Description
The molecular biological revolution and the mapping of the human genome continue to provide new challenges and opportunities for drug research and design. Future medicinal chemists and drug designers must have a firm background in a number of related scientific disciplines in order to understand the conversion of new insight into lead structures and subsequently into drug candidates. Classroom tested and student approved, Textbook of Drug Design and Discovery, Fourth Edition describes the manner in which medicinal chemists utilize the various fields upon which they draw and the specific strategies they employ to advance promising molecules into clinical use for the treatment of disease.
This text integrates a number of related scientific disciplines, including advanced synthetic chemistry, computational chemistry, biochemistry, structural biology, and molecular pharmacology, to provide current and comprehensive information on all aspects of drug design and discovery.
Extensively revised, new topics in the fourth edition include:
Biostructure-based and ligand-based drug design
Chemical biology
Natural products
Imaging
Neurotransmitter transporters
Opioid and cannabinoid receptors
Hypnotics
Neglected diseases
Immunomodulating agents
Antibiotics
The first part of the book covers general aspects, methods, and principles for drug design and discovery, and the second part covers specific targets and diseases. The text contains more than 300 color figures and 24 tables for rapid assimilation. Each chapter includes references for further study. Most chapters also provide the background and history needed to provide a context for students, as well as conclusions that summarize the points most relevant to emerging areas of research in drug design.
Table of Contents
Introduction to Drug Design and Discovery, P. Krogsgaard-Larsen and L. Bunch
Molecular Recognition in Ligand-Protein Binding, T. Liljefors
Biostructure-Based Drug Design, F. S. Jorgensen and J. S. Kastrup
Ligand-Based Drug Design, I. Pettersson, T. Balle, and T. Liljefors
Chemical Biology, K. Stromgaard
Stereochemistry in Drug Design, M. B. Mayo-Martin and D. E. Jane
Natural Products in Drug Discovery, G. T. Carter
Imaging in Drug Discovery and Development, M. Rudin and T. Mueggler
Peptides and Peptidomimetics, M. Cai, V. V. Kulkarni, and V. J. Hruby
Prodrugs: Design and Development, A. Buur and N. Mork
Metals in Medicine: Inorganic Medicinal Chemistry, H. R. Hansen and O. Farver
Enzyme Inhibitors: Biostructure-Based and Mechanism-Based Designs, R. A. Copeland, R. R. Gontarek, and L. Luo
Receptors: Structure, Function, and Pharmacology, H. Brauner-Osborne
Ion Channels: Structure and Function, S.-P. Olesen and D. B. Timmermann
Neurotransmitter Transporters: Structure and Function, C. J. Loland and U. Gether
GABA and Glutamic Acid Receptor Ligands, B. Frolund and U. Madsen
Acetylcholine, A. A. Jensen and P. Krogsgaard-Larsen
Histamine Receptors, I. de Esch, H. Timmerman, and R. Leurs
Dopamine and Serotonin, B. Bang-Andersen and K. P. Bogeso
Opioid and Cannabinoid Receptors, R. P. Clausen and H. S. Hansen
Hypnotics, B. Ebert and K. A. Wafford
Neglected Diseases, S. B. Christensen
Immunomodulating Agents, U. G. Sidelmann
Anticancer Agents, F. Bjoerkling and L. H. Jensen
Antiviral Drugs, E. De Clercq
Antibiotics, P. Herdewijn
Index
by "Nielsen BookData"