Metallothioneins in biochemistry and pathology
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Bibliographic Information
Metallothioneins in biochemistry and pathology
World Scientific, c2008
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Note
Includes bibliographical references and index
Description and Table of Contents
Description
Metallothioneins (MTs) represent a large family of proteins characterized by high heavy metal content (mainly CuII and ZnII) and by an unusual cysteine abundance. They have a powerful protective function in all animal tissues, due most likely to their properties as free radical scavengers protecting against oxidative damage. Moreover, the presence and overexpression of MTs in various pathological conditions, such as metal dyshomeostasis, cell proliferation, neurological disorders, and chemotherapy and radiotherapy resistance, could be used as an important prognostic marker, as a histopathological diagnostic tool, and to follow specific pharmacological treatments.This important book explores the role of MTs in the field of neurological disorders (brain inflammation, Alzheimer's and prion diseases, autism, ALS, etc.), cardiology (cardiomyopathy, atherosclerosis), and oncology (melanoma, prostate and breast cancer), through authoritative contributions and a description of basic biochemical information and paradigmatic pathological events.
Table of Contents
- Metallothioneins and Neurological Disorders: Chemical Structure of Metallothionein (M Vasak)
- MT and Oxidative Stress (W Maret)
- MT in Neurodegenerative Diseases (P Zatta)
- MT in Brain Inflammation (J Hidalgo & M Penkowa)
- MT and Autism (M Aschner)
- MT and Neuronal Injury (R S Chung & A West)
- Metallothionein in Oncology: MT in Oncology (S E Theocharis)
- MT and Melanoma (G Weinlich)
- MT and Brest Cancer (B-H Bay)
- MT and Prostate Cancer (C Balaji)
- MT and Colorectal Tumors (N Aoyama)
- Metallothionein in Cardiopathy: Metallothionein in Cardiomyopathy (L Cai)
- Metallothionein and Atherosclerosis (E Moccheggiani).
by "Nielsen BookData"
