G protein-coupled receptors in health and disease

Author(s)

• Tao, Ya-Xiong

Bibliographic Information

G protein-coupled receptors in health and disease

edited by Ya-Xiong Tao

（Progress in molecular biology and translational science, v. 88-89）

Academic Press, c2009

• pt. A
• pt. B

Note

Includes bibliographical references and index

Description and Table of Contents

Volume

pt. B ISBN 9780123747563

Description

G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. They are also responsible for our sensing of exogenous stimuli, including photons and odorants. GPCRs regulate almost every aspect of our physiological functions. It is estimated that 40% to 50% of currently used therapeutic drugs target GPCRs directly or indirectly. Because the current drugs target only a small portion of the GPCRs, opportunities for targeting the remaining GPCRs is enormous. This volume reviews the latest developments in this rapidly advancing field.

Table of Contents

1. Diseased G protein-coupled receptors: An Introduction Ya-Xiong Tao 2. GPR56 and its related diseases Xianhua Piao and Ze Tian 3. GnRHR mutations and hypogonadotropic hypogonadism Nicholas de Roux 4. LHR mutations and reproductive disorders Deborah L. Segaloff 5. FSHR mutations and reproductive disorders Ya-Xiong Tao and Deborah L. Segaloff 6. V2R mutations and nephrogenic diabetes insipidus Daniel G. Bichet 7. Calcium-sensing receptor mutations Geoffrey N. Hendy 8. Diseases caused by prostacyclin receptor mutations John Hwa and Kathleen A Martin

Volume

pt. A ISBN 9780123747570

Description

G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. They are also responsible for our sensing of exogenous stimuli, including photons and odorants. GPCRs regulate almost every aspect of our physiological functions. It is estimated that 40% to 50% of currently used therapeutic drugs target GPCRs directly or indirectly. Because the current drugs target only a small portion of the GPCRs, opportunities for targeting the remaining GPCRs is enormous. This volume reviews the latest developments in this rapidly advancing field.

Table of Contents

1. Rhodopsin-Mediated Retinitis PigmentosaKatherine M. Malanson and Janis Lem2. Human Diseases Associated with GPR54 MutationsMilena Gurgel Teles, Leticia Ferreira Gontijo Silveira, Suzy Bianco and Ana Claudia Latronico3. Diseases Associated with Growth Hormone-releasing hormone Receptor (GHRHR) MutationsMarco Martari and Roberto Salvatori4. The Melanocortin-1 Receptor Gene Polymorphism and Association with Human Skin CancerKimberley A. Beaumont, Yan Yan Liu and Richard A. Sturm5. The Molecular Basis of Adrenocorticotrophin Resistance Syndrome Lucila L K Elias and Adrian J L Clark6. Mutations in melanocortin-4 receptor and human obesityYa-Xiong Tao

by "Nielsen BookData"

Details

• NCID: BB01677075
• ISBN:
  • 9780123747570
  • 9780123747563
• Country Code: ne
• Title Language Code: eng
• Text Language Code: eng
• Place of Publication: Amsterdam
• Pages/Volumes: 2 v.
• Size: 24 cm
• Classification:
  • DC22 : 612.01575
• Subject Headings:
  • LCSH : G proteins -- Receptors
  • LCSH : G proteins -- Health aspects
  • LCSH : Cellular signal transduction
• Parent Bibliography ID:
  • BA88526923