The chemical biology of nucleic acids

Author(s)

• Mayer, Günter

Bibliographic Information

The chemical biology of nucleic acids

edited by Günter Mayer

Wiley, 2010

Note

Includes bibliographical references and index

Contents of Works

• Chemical synthesis of modified RNA / Claudia Höbartner and Falk Wachowius
• Expansion of the genetic alphabet in nucleic acids by creating new base pairs / Ichiro Hirao and Michiko Kimoto
• Chemical biology of DNA replication : probing DNA polymerase selectivity mechanisms with modified nucleotides / Andreas Marx
• Nucleic-acid-templated chemistry / Michael Oberhuber
• Chemical biology of peptide nucleic acids (PNAs) / Peter E. Nielsen
• The interactions of small molecules with DNA and RNA / Yun Xie, Victor K. Tam and Yitzhak Tor
• The architectural motifs of folded RNAs / Valérie Fritsch and Eric Westhof
• Genesis and biological applications of locked nucleic acids (LNAs) / Harleen Kaur and Souvik Maiti
• Small non-coding RNA in bacteria / Sabine Brantl
• MicroRNA-guided gene silencing / Gunter Meister
• Nucleic acid-based therapies / Britta Hoehn and John J. Rossi
• Innate immune recognition of nucleic acids / Stefan Bauer
• Light-responsive nucleic acids for the spatiotemporal control of biological processes / Alexander Heckel and Günter Mayer
• DNA methylation / Albert Jeltsch and Renata Z. Jurkowska
• Frameworks for programming RNA devices / Maung Nyan Win, Joe C. Liang and Christina D. Smolke
• RNA as a catalyst : the Diels-Alderase ribozyme / Andres Jäschke
• Evolving an understanding of RNA function by in vitro approaches / Qing Wang and Peter J. Unrau
• The chemical biology of aptamers : synthesis and applications / Günter Mayer and Bernhard Wulffen
• Nucleic acids as detection tools / Jeffrey C.F. Lam, Sergio Aguirre and Yingfu Li
• Bacterial riboswitch discovery and analysis / Tyler D. Ames and Ronald R. Breaker

Description and Table of Contents

Description

With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: chemical synthesis of modified RNA expansion of the genetic alphabet in nucleic acids by creating new base pairs chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides nucleic-acid-templated chemistry chemical biology of peptide nucleic acids (PNA) the interactions of small molecules with DNA and RNA the architectural modules of folded RNAs genesis and biological applications of locked nucleic acid (LNA) small non-coding RNA in bacteria microRNA-guided gene silencing nucleic acids based therapies innate immune recognition of nucleic acid light-responsive nucleic acids for the spatiotemporal control of biological processes DNA methylation frameworks for programming RNA devices RNA as a catalyst: The Diels-Alderase-Ribozyme evolving an understanding of RNA function by in vitro approaches the chemical biology of aptamers: synthesis and applications nucleic acids as detection tools bacterial riboswitch discovery and analysis The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.

Table of Contents

Foreword vii Preface ix List of Contributors xi 1 Chemical Synthesis of Modified RNA 1 Claudia Hoebartner and Falk Wachowius 2 Expansion of the Genetic Alphabet in Nucleic Acids by Creating New Base Pairs 39 Ichiro Hirao and Michiko Kimoto 3 Chemical Biology of DNA Replication: Probing DNA Polymerase Selectivity Mechanisms with Modified Nucleotides 63 Andreas Marx 4 Nucleic Acid-templated Chemistry 73 Michael Oberhuber 5 Chemical Biology of Peptide Nucleic Acids (PNAs) 103 Peter E. Nielsen 6 The Interactions of Small Molecules with DNA and RNA 115 Yun Xie, Victor K. Tam and Yitzhak Tor 7 The Architectural Motifs of Folded RNAs 141 Valerie Fritsch and Eric Westhof 8 Genesis and Biological Applications of Locked Nucleic Acids (LNAs) 175 Harleen Kaur and Souvik Maiti 9 Small Non-coding RNA in Bacteria 199 Sabine Brantl 10 MicroRNA-guided Gene Silencing 223 Gunter Meister 11 Nucleic Acid-based Therapies 233 Britta Hoehn and John J. Rossi 12 Innate Immune Recognition of Nucleic Acids 261 Stefan Bauer 13 Light-responsive Nucleic Acids for the Spatiotemporal Control of Biological Processes 279 Alexander Heckel and Gunter Mayer 14 DNA Methylation 307 Albert Jeltsch and Renata Z. Jurkowska 15 Frameworks for Programming RNA Devices 323 Maung Nyan Win, Joe C. Liang and Christina D. Smolke 16 RNA as a Catalyst: The Diels-Alderase Ribozyme 339 Andres Jaschke 17 Evolving an Understanding of RNA Function by In Vitro Approaches 355 Qing Wang and Peter J. Unrau 18 The Chemical Biology of Aptamers: Synthesis and Applications 377 Gunter Mayer and Bernhard Wulffen 19 Nucleic Acids as Detection Tools 401 Jeffrey C.F. Lam, Sergio Aguirre and Yingfu li 20 Bacterial Riboswitch Discovery and Analysis 433 Tyler D. Ames and Ronald R. Breaker Index 455

by "Nielsen BookData"

Details

• NCID: BB02273468
• ISBN:
  • 9780470519745
• LCCN: 2010000254
• Country Code: uk
• Title Language Code: eng
• Text Language Code: eng
• Place of Publication: Chichester, UK
• Pages/Volumes: xiii, 464 p., [16] p. of plates
• Size: 26 cm
• Classification:
  • LCC : QP620
  • NLM : QU 58
  • DC22 : 572.8
• Subject Headings:
  • LCSH : Nucleic acids
  • MESH : Nucleic Acids -- chemistry
  • MESH : Nucleic Acids -- physiology
  • MESH : Nucleic Acids -- therapeutic use