Endotoxemia and endotoxin shock : disease, diagnosis and therapy
Author(s)
Bibliographic Information
Endotoxemia and endotoxin shock : disease, diagnosis and therapy
（Contributions to nephrology, v. 167）
Karger, 2010
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Note
Includes bibliographical references and indexes
Contents of Works
- Endotoxin in the pathogenesis of sepsis / Marshall, J.C.
- Endotoxins and other sepsis triggers / Opal, S.M.
- Rationale of extracorporeal removal of endotoxin in sepsis : theory, timing and technique / Ronco, C.; Piccinni, P.; Kellum, J.
- Extracorporeal removal of endotoxin : the polymyxin B-immobilized fiber cartridge / Tani, T. ... [et al.]
- Mechanisms of polymyxin B endotoxin removal from extracorporeal blood flow : molecular interactions / Vesentini, S., Soncini, M., Fiore, G.B., Redaelli, A.
- Mechanisms of polymyxin B endotoxin removal from extracorporeal blood flow : hydrodynamics of sorption / Fiore, G.B. ... [et al.]
- Endotoxin removal by polymyxin B immobilized cartridge inactivates circulating proapoptotic factors / Martin, E.L., Ranieri, V.M.
- Polymyxin-B hemoperfusion and endotoxin removal : lessons from a review of the literature / Cruz, D.N. ... [et al.]
- PMX endotoxin removal in the clinical practice : results from the EUPHAS trial / Antonelli, M. ... [et al.] on behalf of the EUPHAS Study Group
- Early management of endotoxemia using the endotoxin activity assay and polymyxin B-based hemoperfusion / Novelli, G. ... [et al.]
- Endotoxin activity level and septic shock : a possible role for specific anti-endotoxin therapy? / Monti, G. ... [et al.]
- Endotoxin removal : how far from the evidence? : from EUPHAS to EUPHRATES / Rachoin, J.-S. ... [et al.]
- Endotoxin removal : how far from the evidence? : the EUPHAS 2 project / Martin, E.L. ... [et al.]
Description and Table of Contents
Description
The presence of endotoxin in the bloodstream is the consequence of an immunological response triggered by bacterial invasion of the host. This condition leads to altered cardiovascular function, lung dysfunction and acute kidney injury. Removing as much as possible of the circulating endotoxin is therefore imperative to mitigate its biological and clinical effects at the cellular, tissue and organ levels. The publication at hand summarizes the basic mechanisms, rationale and clinical results of a new therapeutic approach that promises to attain this goal: It consists of a specific hemoperfusion process that utilizes cartridges with immobilized polymixin B in an extracorporeal circuit. Containing contributions by renowned researchers, this book represents as a milestone in the field of extracorporeal therapies in sepsis. It will be a valuable reference work for both basic scientists and clinical professionals who want to keep abreast of current developments.
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