Melanocortins : multiple actions and therapeutic potential

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書誌事項

Melanocortins : multiple actions and therapeutic potential

edited by Anna Catania

（Advances in experimental medicine and biology, v. 681）

Springer Science+Business Media , Landes Bioscience, c2010

大学図書館所蔵 件 / 全3件

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注記

Includes bibliographical references and index

収録内容

  • Structure-activity relationships (SAR) of melanocortin and agouti-related (AGRP) peptides / Anamika Singh, Erica M. Haslach, and Carrie Haskell-Luevano
  • Melanocortin signalling mechanisms / Paula C. Eves and John W. Haycock
  • Distribution and function of melanocortin receptors within the brain / Kathleen G. Mountjoy
  • Drugs, exercise, and the melanocortin-receptor : different means, same ends : treating obesity / Jay W. Schaub, Erin B. Bruce, and Carrie Haskell-Luevano
  • Melanocortins in brain inflammation : the role of melanocortin receptor subtypes / Ruta Muceniece and Maija Dambrova
  • Melanocortins and the cholinergic anti-inflammatory pathway / Daniela Giuliani ... [et al.]
  • Melanocortin control of cell trafficking in vascular inflammation / Hetal B. Patel ... [et al.]
  • Terminal signal : anti-inflammatory effects of melanocyte stimulating hormone related peptides beyond the pharmacophore / Thomas Brzoska ... [et al.]
  • Protective effects of melanocortins in systemic host reactions / Stefano Gatti ... [et al.]
  • Development of melanocortin analogs for melanoma prevention and targeting / Zalfa A. Abdel-Malek
  • MSH radiopeptides for targeting melanoma metastases / Alex N. Eberle ... [et al.]
  • Applications of the role of MSH in ocular immune privilege / Andrew W. Taylor and Darren Lee

内容説明・目次

内容説明

It is clear that the melanocortins are of immense academic interest. Further, these molecules have remarkable potential as pharmaceutical agents for treatment of multiple human and veterinary disorders and diseases. The evidence to support academic interest and clinical applications lies in significant part within the chapters of this book, chapters written by noted experts in the field who have worked diligently to understand the molecules and to move them toward clinical applications. I personally believe that the - MSH molecule and its derivatives will be used as routine therapeutics in the very near future. My belief is so strong that I left academia to form a company based on -MSH analogs and have caused millions of dollars to be spent on melanocortin research. Now why would a sane professor pick up such a challenge and enter business, an essential step toward any clinical application? It is the - MSH story that drove me. Consider that - MSH occurs in exactly the same amino acid sequence in humans and in the sea lamprey, an organism unchanged since its appearance during the Pennsylvanian period of the Paleozoic era (about 300 million years ago-way before dinosaurs were to be considered). There is unpublished evidence that the stability of the molecule can be traced back a half billion years. Frankly, I believe that the molecule existed even when single cells began to live together.

目次

1. Structure?Activity Relationships (SAR) of Melanocortin and Agouti?Related (AGRP) Peptides Anamika Singh, Erica M. Haslach and Carrie Haskell?Luevano Abstract Introduction Structure and Chemistry of Melanocortin Peptides Structure?Activity Relationships (SAR) Agouti?Related Protein (AGRP) Development of Chimeric Peptide Analogues Conclusion 2. Melanocortin Signalling Mechanisms Paula C. Eves and John W. Haycock Abstract Introduction Melanocortin Receptors Melanocortins and Pigmentation Melanocortin Anti?Inflammatory and Immunomodulatory Roles Intracellular Signalling of Melanocortin Peptides Melanocortin Receptor Antagonists and Agonists Conclusion 3. Distribution and Function of Melanocortin Receptors within the Brain Kathleen G. Mountjoy Abstract Introduction MC1R Is Expressed in the Periaqueductal Gray and the MC1R Regulates Pain and Analgesia MC2R Is Expressed in Teleost Fish Brain and Fetal Mouse Brain, but Not in Adult Mammalian Brain MC3R Is Specifically Expressed in Hypothalamus and the Limbic System Where Its Functions Are Not Clearly Understood MC4R Is Expressed in Distinct Nuclei in Every Region of the Brain Reflecting It's Many Diverse Functions in the Brain MC5R Expression and Function in the Brain Is Unclear Melanocortin Receptor Accessory Proteins (MRAPs) Conclusion 4. Drugs, Exercise, and the Melanocortin?4 Receptor-Different Means, Same Ends: Treating Obesity Jay W. Schaub, Erin B. Bruce, and Carrie Haskell?Luevano Abstract Introduction Melanocortins Exercise Conclusion 5. Melanocortins in Brain Inflamation: The Role of Melanocortin Receptor Subtypes Ruta Muceniece and Maija Dambrova Abstract Introduction Distribution of MC Expressing Neurons and MC Receptors in the Brain MCR Subtypes and Brain Inflammation Main Intracellular Signalling Pathways of MC Receptors Potential Therapeutic Applications of MC Receptor Subtype Selective Compounds Conclusion 6. Melanocortins and the Cholinergic Anti?Inflamatory Pathway DanielaGiuliani, Alessandra Ottani, Domenica Altavilla, Carla Bazzani, Francesco Squadrito and Salvatore Guarini Abstract Introduction The Inflammatory Reflex Antishock Effects of Melanocortins Melanocortins Reverse Circulatory Shock through Activation of the Cholinergic Anti?Inflammatory Pathway Protective Effect of Melanocortins in Myocardial Ischemia/Reperfusion Melanocortins Prevent Myocardial Ischemia/Reperfusion?Induced Damage through Activation of the Cholinergic Anti?Inflammatory Pathway Neuroprotection by Melanocortins in Ischemic Stroke Melanocortins Produce Neuroprotection Against Ischemic Stroke by Activating the Cholinergic Anti?Inflammatory Pathway Conclusion 7. Melanocortin Control of Cell Traficking in Vascular Inflamation Hetal B. Patel, Giovanna Leoni, Trinidad Montero Melendez, Andre L.F. Sampaio and Mauro Perretti Abstract Introduction Inflammation: Cell Trafficking and Microcirculation Melancortins in Experimental Inflammation Effects of Melanocortins on Inflammatory Cells In Vitro Lessons from Melanocortin Knockout Mice Drug Discovery Melanocortin Peptide Pharmacology Conclusion 8. Terminal Signal: Anti?Inflamatory Efects of ??Melanocyte?Stimulating Hormone Related Peptides Beyond the Pharmacophore Thomas Brzoska, Markus Boehm, Andreas Lugering, Karin Loser and Thomas A. Luger Abstract Introduction ??MSH Related Peptides and Melanocortin Receptors-Mediation of Anti?Inflammatory Effects? Anti?Inflammatory Effects of ??MSH Related Tripeptides In Vitro and Vivo Therapeutic Potential of ??MSH?Related Tripeptides in Human Immune?Mediated Inflammatory Diseases Conclusion 9. Protective Efects of Melanocortins in Systemic Host Reactions Stefano Gatti, Caterina Lonati, Andrea Sordi and Anna Catania Abstract Introduction Fever Endotoxemia and Septic Shock Acute Respiratory Distress Syndrome (ARDS) Ischemia and Reperfusion Injury Organ Transplantation Conclusion 10. Development of ??Melanocortin Analogs for Melanoma

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