Neuropsychological endophenotypes and biomarkers
著者
書誌事項
Neuropsychological endophenotypes and biomarkers
(The handbook of neuropsychiatric biomarkers, endophenotypes and genes / Michael S. Ritsner, editor, v. 1)
Springer, c2009
- : hbk
大学図書館所蔵 全5件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
内容説明・目次
内容説明
Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer's disease, epilepsy, alcoholism, substance abuse and others are some of the most debilitating illnesses worldwide characterizing by the complexity of the causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunity to understand the etiology and the underlying pathophysiological mechanisms of neuropsychiatric disorders. The challenge now is to translate these advances into meaningful diagnostic and therapeutic advances.
This book offers a broad synthesis of the current knowledge about diverse topics of the biomarker and endophenotype strategies in neuropsychiatry. The book is organized into four interconnected volumes: "Neuropsychological Endophenotypes and Biomarkers" (with overview of methodological issues of the biomarker and endophenotype approaches in neuropsychiatry and some technological advances), "Neuroanatomical and Neuroimaging Endophenotypes and Biomarkers", "Metabolic and Peripheral Biomarkers" and "Molecular Genetic and Genomic Markers". The contributors are internationally and nationally recognized researchers and experts from 16 countries.
This four-volume handbook is intended for a broad spectrum of readers including neuroscientists, psychiatrists, neurologists, endocrinologists, pharmacologists, clinical psychologists, general practitioners, geriatricians, health care providers in the field of neurology and mental health interested in trends that have crystallized in the last decade, and trends that can be expected to further evolve in the coming years. It is hoped that this book will also be a useful resource for the teaching of psychiatry, neurology, psychology and mental health.
目次
Foreword
Contributors Part I. Methodological and Technological Advances
1. Where do we stand in the quest for neuropsychiatric biomarkers and endophenotypes and what next? Michael S. Ritsner and Irving I. Gottesman
2. Methodological and statistical issues in the use of biomarkers in clinical and research studies. Ryan Van Lieshout and Peter Szatmari
3. Challenging the genetic complexity of schizophrenia by use of endophenotypes. Assen Jablensky
4. Translational medicine: functional biomarkers for drug development of 'cognitive enhancers' in schizophrenia. Georg Winterer
5. Leveraging high-dimensional neuroimaging data in genetic studies of neuropsychiatric disease. Cinnamon S. Bloss, Trygve E. Bakken, Alexander H. Joyner, Nicholas J. Schork
6. Proteomics as a new tool for biomarker-discovery in neuropsychiatric disorders. Thomas J. Raedler, Harald Mischak, Holger Jahn, Klaus Wiedemann
7. Schizophrenia endophenotypes as treatment targets. Stephen I. Deutsch, Barbara L. Schwartz, Richard B. Rosse, John Mastropaolo, Ayman H. Fanous, Abraham Weizman, Jessica A. Burket, Brooke L. Gaskins Part II. Neuropsychological, Neurocognitive and Neurophysiological Domains
8. Neuropsychological endophenotypes in schizophrenia and bipolar I disorder: yields from the Finnish family and twin studies. Annamari Tuulio-Henriksson, Jonna Perala, Irving I. Gottesman and Jaana Suvisaari
9. Is more cognitive experimental psychopathology of schizophrenia really necessary? Challenges and opportunities. Angus MacDonald, III
10. Intellectual functioning as an endophenotype for schizophrenia. Odette de Wilde
11. Emotion recognition deficits as a neurocognitive marker of schizophrenia liability. Renata Schoeman, Dana J. H. Niehaus, Liezl Koen, Jukka M. Leppanen
12. The use of neurocognitiveendophenotypes in large-scale family genetic studies of schizophrenia. William P. Horan, Tiffany A. Greenwood, David L. Braff, Raquel E. Gur and Michael F. Green
13. Neurocognitive endophenotypes for bipolar disorder: evidence from case-control, family and twin studies. Eugenia Kravariti, Fergus Kane, Robin Murray
14. Trait and state markers of schizophrenia in visual processing. Yue Chen, Daniel Norton and Ryan McBain
15. Visual scanning abnormalities as biomarker for schizophrenia and bipolar disorder. Patricia E. G. Bestelmeyer
16. Biomarkers and endophenotypes in eating disorders. Carolina Lopez, Marion Roberts and Janet Treasure
17. Movement abnormalities: a putative biomarker of risk for psychosis. Vijay Mittal and Elaine Walker Afterword by Robert H. Belmaker
Contents of Volumes 2, 3, and 4
Contributors of Volumes 2, 3, and 4
Index
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