CiNii 図書 - Progress in DNA damage research

This book presents the latest research on DNA damage, which due to environmental factors and normal metabolic processes inside the cell, occurs at a rate of 1,000 to 1,000,000 molecular lesions per cell per day. While this constitutes only 0.000165% of the human genome's approximately 6 billion bases (3 billion base pairs), unrepaired lesions in critical genes (such as tumour suppresser genes) can impede a cell's ability to carry out its function and appreciably increase the likelihood of tumour formation. The vast majority of DNA damage affects the primary structure of the double helix; that is, the bases themselves are chemically modified. These modifications can in turn disrupt the molecules' regular helical structure by introducing non-native chemical bonds or bulky adducts that do not fit in the standard double helix. Unlike proteins and RNA, DNA usually lacks tertiary structure and therefore damage or disturbance does not occur at that level. DNA is, however, supercoiled and wound around "packaging" proteins called histones (in eukaryotes), and both superstructures are vulnerable to the effects of DNA damage.

Preface
Progress in Somatic Hypermutation Research
Factors Leading to the Induction and Conversion of DNA Damage into Structural Chromosomal Aberrations
Pesticides as Genetic Damage Inducers
DNA Damage Related to Exposure to Oil Spills: The Prestige Experience
Differentiated Cells Play Favorites: Dissecting the Mechanisms of Discrimination in DNA Repair
Functional Roles for Pro-Apoptotic Kinases on Nuclear Targeting and Induction of Apoptosis in Response to DNA Damage
Biological Significance of DNA Damage Checkpoint and the Mode of Checkpoint Signal Amplification
Cobalt Treatment Suppressing Mitochondrial DNA Damage Caused by Acute Exposure of H2O2
Molecular Basis of Guanine Oxidation Under UV-A/VIS Radiation and its Biological Effects
New Advances on DNA Fragmentation
Sperm Chromatin Damage
Sperm DNA Fragmentation in Assisted Reproduction
Comments on the Clinical Value of Determination of Sperm DNA Fragmentation
Assessing the Fast Micromethod as a Tool in DNA Integrity Analysis
Unconventional Use of the Comet Assay to Identify and Classify Different Nuclear Phenotypes in Cell Cultures
Bromodeoxyuridine-Labeling and DNA repair, When Studying Neurogenesis
Index.

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Progress in DNA damage research

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