Proteins : membrane binding and pore formation
著者
書誌事項
Proteins : membrane binding and pore formation
(Advances in experimental medicine and biology, v. 677)
Springer Science+Business Media , Landes Bioscience, c2010
大学図書館所蔵 全5件
  青森
  岩手
  宮城
  秋田
  山形
  福島
  茨城
  栃木
  群馬
  埼玉
  千葉
  東京
  神奈川
  新潟
  富山
  石川
  福井
  山梨
  長野
  岐阜
  静岡
  愛知
  三重
  滋賀
  京都
  大阪
  兵庫
  奈良
  和歌山
  鳥取
  島根
  岡山
  広島
  山口
  徳島
  香川
  愛媛
  高知
  福岡
  佐賀
  長崎
  熊本
  大分
  宮崎
  鹿児島
  沖縄
  韓国
  中国
  タイ
  イギリス
  ドイツ
  スイス
  フランス
  ベルギー
  オランダ
  スウェーデン
  ノルウェー
  アメリカ
注記
Includes bibliographical references and index
収録内容
- Energetics of peptide and protein binding to lipid membranes / William C. Wimley
- Membrane association and pore formation by alpha-helical peptides / Burkhard Bechinger
- Role of membrane lipids for the activity of pore forming peptides and proteins / Gustavo Fuertes ... [et al.]
- Cholesterol-dependent cytolysins / Robert J.C. Gilbert
- Laetiporus sulphureus lectin and aerolysin protein family / Jose Miguel Manchero .. [et al.]
- Interfacial interactions of pore-forming colicins / Helen Ridley, Christopher L. Johnson and Jeremy H. Lakey
- Permeabilization of the outer mitochondrial membrane by BCL-2 proteins / Ana J. Garcia-Suez ... [et al.]
- Molecular mechanism of sphingomyelin : specific membrane binding and pore formation by actinoporins / Biserka Bakra and Gregor Anderluh
- Hemolysin E (hlye, clya, shea) and related toxins / Stuart Hunt, Jeffrey Green and Peter J. Artymiuk
- Pore formation by cry toxins / Mario Soberin ... [et al.]
- Role of heparan sulfates and glycosphingolipids in the pore formation of basic polypeptides of cobra cardiotoxin / Wen-guey Wu ... [et al.]
- Amyloid peptide pores and the beta sheet conformation / Bruce L. Kagan and Jyothi Thundimadathil
内容説明・目次
内容説明
Formation of transmembrane pores is a very effective way of killing cells. It is thus not surprising that many bacterial and eukaryotic toxic agents are pore-forming proteins. Pore formation in a target membrane is a complex process composed of several steps; proteins need to attach to the lipid membrane, possibly aggregate in the plane of the membrane and finally form a pore by inserting part of the polypeptide chain across the lipid bilayer. Structural information about toxins at each stage is indispensible for the biochemical and molecular biological studies that aim to - derstand how pores are formed at the molecular level. There are currently only two Staphylococcus aureus and hemolysin E from Escherichia coli. Therefore, what we know about these proteins was obtained over many years of intense experimentation. We have nevertheless, in the last couple of years, witnessed a significant rise in structural information on the soluble forms of pore-forming proteins. Surprisingly, many unexpected similarities with other proteins were noted, despite extremely low or insignificant sequence similarity. It appears that lipid membrane binding and formation of transmembrane channels is achieved in many cases by a limited repertoire of structures. This book describes how several of the important pore forming toxin families achieve membrane bi- ing and which structural elements are used for formation of transmembrane pores. Our contributors have thus provided the means for a comparative analysis of several unrelated families.
目次
Energetics of Peptide and Protein Binding to Lipid Membranes.- Membrane Association and Pore Formation by Alpha-Helical Peptides.- Role of Membrane Lipids for the Activity of Pore Forming Peptides and Proteins.- Cholesterol-Dependent Cytolysins.- Laetiporus sulphureus Lectin and Aerolysin Protein Family.- Interfacial Interactions of Pore-Forming Colicins.- Permeabilization of the Outer Mitochondrial Membrane by Bcl-2 Proteins.- Molecular Mechanism of Sphingomyelin-Specific Membrane Binding and Pore Formation by Actinoporins.- Hemolysin E (HlyE, ClyA, SheA) and Related Toxins.- Pore formation by Cry toxins.- Role of Heparan Sulfates and Glycosphingolipids in the Pore Formation of Basic Polypeptides of Cobra Cardiotoxin.- Amyloid Peptide Pores and the Beta Sheet Conformation.
「Nielsen BookData」 より