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pt. 1. Basic research ISBN 9780444536143
Description
This first volume starts with an overview on current perspectives in genetic research and on the molecular mechanisms of neurodegeneration. This is followed by a selection of hot topics in pathophysiological research, from molecular studies to system-level investigations based on in vivo electrophysiological recordings and neurocomputational methods.
Table of Contents
Section I: Genetic and molecular mechanisms of neurodegeneration in PD 1. Identifying PD-causing genes and genetic susceptibility factors: current approaches and future prospects 2. The impact of genetic research on our understanding of Parkinson's Disease 3. Unraveling the role of defective genes 4. What causes the death of dopaminergic neurons in Parkinson's disease? 5. Intracellular Signaling Pathways In Dopamine Cell Death And Axonal Degeneration 6. Control of mitochondrial integrity in Parkinson's Disease 7. Role of Post-Translational Modifications in Modulating the Structure, Function and Toxicity of a-synuclein: Implications for Parkinson's Disease Pathogenesis and Therapies
Section II: Cellular and system-level pathophysiology of the basal ganglia in P 8. The role of dopamine in modulating the structure and function of striatal circuits 9. Assemblies of glutamate receptor subunits with post-synaptic density proteins and their alterations in Parkinson's disease 10. Adenosine-dopamine interactions 11. Maladaptive plasticity in L-DOPA-induced dyskinesia 12. Effects of GPi and STN inactivation on physiological, motor, cognitive and motivational processes in animal models of Parkinson's disease 13. Computational physiology of the basal ganglia in Parkinson's disease 14. Neurocomputational models of motor and cognitive deficits in Parkinson's Disease
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pt. 2. Translational and clinical research ISBN 9780444537508
Description
This second volume follows on from Part I by reviewing the variety of animal models of PD current available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research. This is followed by comprehensive coverage of functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients. Different areas of experimental therapeutics and outstanding challenges to PD treatment are presented in a concluding group of articles.
Table of Contents
Section I: Animal models of PD
What have we learned from Drosophila Models of Parkinson's Disease? - Ming Guo
Neurotoxic in vivo models of Parkinson's disease: recent advances - Timothy Greenamyre & Jason R. Cannon
Behavioural analysis of motor and non-motor symptoms in rodent models of Parkinson's disease - Stephen B. Dunnett & Mariah Lelos
Genetic mouse models of Parkinson's disease: the state of the art - Marie-Francoise Chesselet & Iddo Magen
Viral vector mediated overexpression of a-synuclein as a progressive model of Parkinson's disease - Anders Bjorklund, Ayse Ulusoy, Mickael Decressac, Deniz Kirik
Modelling inflammatory pathogenesis of Parkinson's Disease - Malu Tansey & Christopher J. Barnum
The MPTP-lesioned non-human primate models of Parkinson's disease. Past, present and future - Susan Fox & Jonathan Brotchie
Section II: Exploring PD with brain imaging
Abnormal Metabolic Brain Networks in Parkinson's Disease: From Blackboard to Bedside - David Eidelberg & Chris C. Tang
Imaging the Nigrostriatal System to Monitor Disease Progression and Treatment-Induced Complications - Jon Stoessl & Renju Kuriakose
Brain imaging after neural transplantation - Paola Piccini & Marios Politis
Imaging non-motor aspects of Parkinson's disease - David Brooks & Nicola Pavese
Section III: Frontiers in PD treatment
Gene therapy for dopamine replacement - Deniz Kirik & Tomas Bjoerklund, Erik Ahlm Cederfjall
Neurotrophic Factor Therapy for Parkinson's disease - Jeffrey Kordower, Rangasamy Suresh Babu, Katherine Soderstrom, Roy A.E. Bakay
Neural grafting in Parkinson's disease: Problems and possibilities - Patrik Brundin, Roger A Barker and Malin Parmar
Neural grafting in Parkinsons disease: Unraveling the mechanisms underlying graft-induced dyskinesia - Emma L Lane, Anders Bjoerklund, Stephen B Dunnett, Christian Winkler
Deep Brain Stimulation: State of the Art and Novel Stimulation Targets - Andres Lozano & Francisco A. Ponce
The challenge of Non-Motor Symptoms in Parkinsons Disease - Ray Chaudhuri & Per Odin
by "Nielsen BookData"
