Epigenetics, disease and behaviour
著者
書誌事項
Epigenetics, disease and behaviour
（Essays in biochemistry, v. 48）
Portland Press, c2010
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注記
Includes bibliographical references and index
Series editor: Melanie Welham (U.K.)
内容説明・目次
内容説明
Epigenetic mechanisms provide a series of regulatory principles that define potentially stable and heritable changes in gene expression without altering the genetic information that is encoded within DNA. In understanding how epigenetic regulation defines cell type, it may also define patterns of gene expression that correlate with changes in behaviour and disease. The study of epigenetics reveals the complexity of regulatory mechanisms that control gene expression. This volume of Essays in Biochemistry provides an appraisal of the fundamental principles that facilitate the epigenetic regulation of chromatin function, with particular attention on the relevance to human disease and behaviour.
目次
- Evolutionary origin of the cell nucleus and its functional architecture
- Spatial epigenetics: linking nuclear structure and function in higher eukaryotes
- Epigenetic markers and their cross-talk
- Nucleosome dynamics and epigenetic stability
- Nucleosome dynamics and histone variants
- RNA-directed epigenetic regulation of DNA rearrangements
- Non-Mendelian epigenetic heredity: gametic RNAs as epigenetic regulators and transgenerational signals
- Epigenetic dynamics across the cell cycle
- Epigenetic regulation of cell life and death decisions and deregulation in cancer
- Dynamics of telomeric chromatin at the crossroads of aging and cancer
- MicroRNAs, epigenetics and disease
- Genomic imprinting and human disease
- Epigenetics and transcriptional control in African trypanosomes
- Epigenetic regulation of V(D)J recombination
- Chromatin plasticity in pluripotent cells
- Epigenetic regulation of genes in learning and memory
- Environmental epigenomics: understanding the effects of parental care on the epigenome
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