BCL-2 protein family : essential regulators of cell death

著者

    • Hetz, Claudio

書誌事項

BCL-2 protein family : essential regulators of cell death

edited by Claudio Hetz

（Advances in experimental medicine and biology, v. 687）

Springer Science+Business Media , Landes Bioscience, c2010

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注記

Includes bibliographical references and index

収録内容

  • Homeostatic functions of BCL-2 proteins beyond apoptosis / Nika N. Danial, Alfredo Gimenez-Cassina, and Daniel Tondera
  • Alternative functions of the BCL-2 protein family at the endoplasmic reticulum / Diego Rojas-Rivera ... [et al.]
  • BH3-only proteins and their effects on cancer / Thanh-Trang Vo and Anthony Letai
  • Endoplasmic reticulum stress and BCL-2 family members / Ross T. Weston and Hamsa Puthalakath
  • Targeting survival pathways in lymphoma / Luca Paoluzzi and Owen A. O'Connor
  • The interplay between BCL-2 family proteins and mitochondrial morphology in the regulation of apoptosis / Maria Eugenia Soriano and Luca Scorrano
  • Noncanonical functions of BCL-2 proteins in the nervous system / Heather M. Lamb and J. Marie Hardwick
  • Mitochondria on guard : role of mitochondrial fusion and fission in the regulation of apoptosis / Mariusz Karbowski

内容説明・目次

内容説明

In this book, scientists pioneering the field have compiled a series of focused chapters to highlight the relevance of the BCL-2 family of proteins in apoptosis, physiology and disease. An important focus of this volume is considering the potential TH ERA PEUT IC benefits of targeting apoptosis pathways in the context of human disease. Readers interested in understanding how a cell handles stress and the consequences of dysregulation of this process for human disease will find this book very valuable. It attempts to describe a fascinating area of research where physiology and biomedicine converge at different levels, revealing a trip from the molecular regulation of apoptosis to the impact of this process to the physiology of a whole organism.

目次

1. Homeostatic Functions of BCL?2 Proteins Beyond Apoptosis Nika N. Danial, Alfredo Gimenez?Cassina and Daniel Tondera Abstract Mitochondrial Energy Metabolism Autophagy Protein Quality Control and the Unfolded Protein Response Physiologic Roles for BCL?2 Family Proteins in Cell Cycle Checkpoints, Differentiation and DNA Damage Response Conclusion 2. Alternative Functions of the BCL?2 Protein Family at the Endoplasmic Reticulum Diego Rojas?Rivera, Benjamin Caballero, Sebastian Zamorano, Fernanda Lisbona and Claudio Hetz Abstract Introduction The BCL?2 Protein Family and the Unfolded Protein Response Chronic ER Stress and BH3?Only Proteins The BCL?2 Protein Family and the Calcium Rheostat Autophagy and the BCL?2 Protein Family of Proteins Conclusion 3. BH3?Only Proteins and Their Efects on Cancer Thanh?Trang Vo and Anthony Letai Abstract Introduction Categories of BCL?2 Family Proteins and Their Apoptotic Functions Regulation of Various BH3?Only Proteins and Cell Stress Sensing BH3?Only Proteins and Cancer Development BH3?Only Proteins and Chemotherapy Response and Resistance BH3?only Mimetic Drugs Conclusion 4. Endoplasmic Reticulum Stress and BCL?2 Family Members Ross T. Weston and Hamsa Puthalakath Abstract Introduction UPR: The Good and the Evil Side UPR and BCL?2 Family Members Autophagy, UPR and BCL?2 Family Members Conclusion 5. Targeting Survival Pathways in Lymphoma Luca Paoluzzi and Owen A. O'Connor BCL?2 Family of Proteins and Cell Death Abstract Introduction Pharmacologic Modulation of BCL?2 Proteins and Apoptosis BCL?2 Proteins and Non?Apoptotic Cell Death Conclusion 6. The Interplay between BCL?2 Family Proteins and Mitochondrial Morphology in the Regulation of Apoptosis Maria Eugenia Soriano and Luca Scorrano Abstract Introduction BCL?2 Family Mitochondrial Shape and Apoptosis Conclusion 7. Noncanonical Functions of BCL?2 Proteins in the Nervous System Heather M. Lamb and J. MarieHardwick Abstract Introduction Extending the Traditional View of BCL?2 Family Proteins Challenging the Traditional BCL?2 Family Model BCL?2 Family Proteins in the Nervous System When Anti?Death BCL?2 Proteins Become Pro?Death When Pro?Death BCL?2 Proteins Protect Neurons Protection Predicts New Functions with a Seizure BCL?2 Family Proteins Regulate Synaptic Activity Mitochondrial Dynamics in Neuronal Function Conclusion 8. Mitochondria on Guard: Role of Mitochondrial Fusion and Fission in the Regulation of Apoptosis Mariusz Karbowski Abstract Introduction Regulation of Mitochondrial Fusion and Fission Mitochondrial Network Dynamics and Cell Homeostasis Role of Mitochondrial Dynamics in Cell Death Mechanism of the OM Permeabilization: A Vital Role for Mitochondrial Fusion and Fission? Emerging Evidence for the Role of BCL?2 Family Proteins in the Regulation of Mitochondrial Network Dynamics in Healthy Cells Conclusion Index

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